摘要
The GeCl 3, Ge(OH) 3, GeO 3 and GeO 1/2 moieties have been introduced to sulfonyldianiline, carbamazepine and norfloxacin, respectively, to give four medicines containing germanium. The structures of the medicines prepared were characterized by IR, 1H NMR and elemental analysis. The biological tests showed that the new compounds have anticancerous activity, among them the compound prepared from sulfonyldianiline(2000-1) has inhibitory rate of 88 6% at dosage of 1×10 -4 mol/L.
The GeCl 3, Ge(OH) 3, GeO 3 and GeO 1/2 moieties have been introduced to sulfonyldianiline, carbamazepine and norfloxacin, respectively, to give four medicines containing germanium. The structures of the medicines prepared were characterized by IR, 1H NMR and elemental analysis. The biological tests showed that the new compounds have anticancerous activity, among them the compound prepared from sulfonyldianiline(2000-1) has inhibitory rate of 88 6% at dosage of 1×10 -4 mol/L.
出处
《应用化学》
CAS
CSCD
北大核心
2004年第1期101-103,共3页
Chinese Journal of Applied Chemistry
