摘要
β-羧基乙基锗倍半氧化物(即Ge-132)是一种无毒和具较强抗癌活性的有机锗化合物。为了进一步提高其抗癌活性。已对Ge-132进行了化学结构修饰。本文介绍8种未见报导的Ge-132衍生物,β-酚酯基乙基锗倍半氧化物的合成和体外培养细胞实验结果。
Eight compounds of (GcCH_2CH_2COOAr)_2O_3 type were synthesized. Their constitutesand structures were determined by elemental analysis and IR specrophotometry. Three ofthem were tested for antitumour activities against Hela cells in vitro, showing some tumourinhibitory activity. Their effects on diploid cell were not obvious in mitosis and shape.
出处
《应用化学》
CAS
CSCD
北大核心
1989年第5期59-62,共4页
Chinese Journal of Applied Chemistry
关键词
有机锗化合物
合成
抗癌活性
Organogermanium compound
Synthesis
Antitumour activity
