摘要
目的 探讨病毒性脑炎 (VE)患儿治疗前血清、脑脊液和治疗后血清白细胞介素 6 (IL 6 )和肿瘤坏死因子 α(TNF α)在VE患儿发病中的作用 ,为寻找有效的治疗方案提供理论依据。方法 2 5例VE患儿 (重症组 15例和轻症组 10例 )均采用ELISA法测定其治疗前血清、脑脊液及治疗后血清IL 6和TNF α水平 ,并与正常对照组比较。结果 治疗前轻症组和重症组血清和脑脊液IL 6、TNF α浓度均较对照组明显升高 (P均 <0 .0 1) ,且重症组较轻症组明显升高 ,有显著性差异 (P <0 .0 1)。轻症组治疗后血清IL 6和TNF α浓度与对照组比较差异无统计学意义 (P >0 .0 5 ) ,而重症组治疗后血清IL 6和TNF α浓度仍显著高于正常对照组 ,且较轻症组亦明显高 (P均 <0 .0 1) ,差异有显著性意义。结论 VE患儿治疗前血清和脑脊液IL 6和TNF α水平显著升高 。
Objective To investigate the changes of interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α) in serum and cerebrospinal fluid (CSF) in children with viral encephalitis (VE) before and after treatment, and to explore the pathogenesis of the cytokins in VE, and try to provide theoretical basis for the treatment of VE.Methods The levels of IL-6 and TNF-α in serum and CSF were determined before treatment by ELISA in 25 children who were admitted with VE, including 15 cases with severe VE(SVE) , another 10 cases with mild VE(MVE), and other 10 children served as normal controls. Serum levels of IL-6 and TNF-α were determined after treatment. Results The levels of IL-6 and TNF-α in serum and CSF before treatment were obviously higher than those of control group, and the difference was significant (P<0.01); CSF IL-6 and TNF-α levels of serum and in SVE group were higher than those of MVE group, and the difference was significant (P<0.01). After treatment, the difference of IL-6 and TNF-α between MVE and control group was of no statistical significance (P>0.05), but IL-6 and TNF-α levels of CSF and serum in SVE group were higher than those of MVE and control group(P<0.01).Conclusions IL-6 and TNF-α levels of serum and CSF and increases in children with VE, and positive correlation can be found between the servers of the disease and IL-6 and TNF-α levels of serum and CSF;immune mechanism may play a role in the pathogenesis of VE.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2003年第12期986-988,共3页
Journal of Applied Clinical Pediatrics
基金
青岛市科技发展基金资助项目 [项目编号 :KZ - 1 5 - 2 0 0 1 ]
