摘要
单核苷酸多态性是指DNA序列上的单个碱基变异,它具有分布广、多态信息含量大、易于检测和统计分析等优点,能较好用于基因图谱构建和数量性状QTL定位研究,被称为继RFLP和微卫星标记之后的第3代基因遗传标记。本文综述了单核苷酸多态性的性质及检测技术、利用候选基因SNP进行鸡QTL定位研究的现状,并对未来SNP的应用前景进行了展望。
Single nucleotide polymorphism (SNP) refers to the change of single nucleotide in DNA sequence.Because of its high density in genomes and easy in detection and analysis statistically,SNP can be used in genetic linkage map construction and QTL mapping.Here,the characters and detecting technology of SNP,as well as the status and foreground of the use of candidate gene SNP in chicken QTL mapping are introduced.
出处
《遗传》
CAS
CSCD
北大核心
2003年第6期729-734,共6页
Hereditas（Beijing)
基金
国家重大基础研究规划项目(编号为G2000016102)
关键词
鸡
单核苷酸多态性
SNP
遗传标记
QTL定位
chicken
single nucleotide polymorphism (SNP)
genetic marker
QTL mapping
