2Tzeng HP,Fan J,Vallejo JG,et al.Negative inotropic effects of high-mobility group box1protein in isolated contracting cardiac myocytes[J].Am J Physiol Heart Circ Physiol,2008,294(3):H1490-H1496.
3Krishnagopalan S,Kumar A,Parrillo JE,et al.Myocardial dysfunction in the patient with sepsis[J].Curr Opin Crit Care,2002,8(5):376-388.
4Parker MM,McCarthy KE,Ognibene FP,et al.Right ventricular dysfunction and dilatation,similar to left ventri-cular changes,characterize the cardiac depression of septic shock in humans[J].Chest,1990,97(1):126-131.
5Reilly JM,Cunnion RE,Burch-Whitman C,et al.A cir-culating myocardial depressant substance is associated with cardiac dysfunction and peripheral hypoperfusion(lactic acidemia)in patients with septic shock[J].Chest,1989,95(5):1072-1080.
6Rittirsch D,Huber-Lang MS,Flierl MA,et al.Immuno-design of experimental sepsis by cecal ligation and puncture[J].Nat Protoc,2009,4(1):31-36.
8Goodwin GH,Sanders C,Johns EW.A new group of chro-matin-associated proteins with a high content of acidic andbasic amino acids[J].Eur J Biochem,1973,38(1):14-19.
9Wang H,Bloom O,Zhang M,et al.HMG-1as a late mediator of endotoxin lethality in mice[J].Science,1999,285(5425):248-251.
10Xu H,Su Z,Wu J,et al.The alarmin cytokine,high mobility group box1,is produced by viable cardiomyo-cytes and mediates the lipopolysaccharide-induced myocar-dial dysfunction via a TLR4/phosphatidylinositol3-kinase gamma pathway[J].J Immunol,2010,184(3):1492-1498.