摘要
目的:寻找减少人体肠道对黄曲霉毒素吸收、增加其排泄的有效手段。方法:随机抽取广州某高校300名健康青年男性学生,尿检AFM1阳性者,志愿者83例随机分为2组,双盲法分别给予乳酸杆菌胶囊和安慰剂胶囊,收集服用胶囊第1周、第3周、第5周和停用胶囊后的粪便样本测定AFT排泄量。结果:男性健康青年学生尿AFM1阳性率50%;乳酸杆菌组第1周第1次粪便样本AFT排泄量显著高于安慰剂组(p<0.05)。结论:广州某高校青年男性学生有较高的AFT污染率;乳酸杆菌可影响人体肠道黄曲霉毒素的排泄,其有效剂量和排泄机制有待于进一步研究。
Objective: Finding certain strains of probiotic lactic acid bacteria will reduce the absorption of dietary aflatoxins from the intestine. Methods: 300 health male students at a university in Guangzhou were screened for the presence of a aflatoxin M1(AFM1) in a urine sample. Based on detectable level of AF M1 in urine in screening, 83 volunteers were enrolled in the trail testing whether the probiotic administration can modulate the levels of aflatoxin in faeces. Results: Nearly 50%(n=142) of the initial population of 300 students in the university who were screened for the detectable level of aflatoxin in their urine. On the first faeces after starting the intervention period the total faecal aflatoxin concentration was significantly higher in the probiotic group than in the placebo group(p<0.05). Conclusion: Health male students are exposed to significant amounts of aflatoxin in Guangzhou. Probiotic lactic acid bacteria altered faecal aflatoxin excretion in population.
