摘要
本文对66例B型超声实时显像显示肝脏有占位性病变患者,手术前同时进行血清铁蛋白、α_1抗胰蛋白酶及甲胎蛋白测定。以阳性预示值及特异性为优先考察指标,兼顾Youden指数及诊断效率,确定血清铁蛋白的切割值男性为300μg/L,女性为180μg/L,α_1抗胰蛋白酶及甲胎蛋白的切割值分别为4.2 g/L及20μg/L。其中55例肝癌患者的血清铁蛋白、α_1抗胰蛋白酶及甲胎蛋白的阳性率分别为0.84、0.71及0.66,但组合分析表明三者均阴性可基本排除肝癌可能,甲胎蛋白阳性可排除肝血管瘤可能。因此组合分析对肝癌的诊断及肝癌与肝做管瘤的鉴别诊断是可取的。
Combined assays of serum ferritin (SF), alpha-1-antitrypsin (AAT) and alpha-fetoprotein (AFP) were conducted preoperatively in sixty six patients with intrahepatic space-occupying lesions confirmed by B-real time ultrasonography. Elevated SF levels (>300 μg/L in males and>180 μg/L in females), AAT levels (>4.2 g/L), and AFP levels (>20 μg/L) were detected respectively in 84%, 71% and 66% of 55 patients with liver cancer. The combined analysis indicates that if all the three tests are negative in results, the probability of liver cancer can be excluded on the whole, and positive AFP can rule out the probability of hepatic hemangioma. Thus the combined assays of SF, AAT and AFP are valuable in the diagnosis of liver cancer, and helpful as well in the differential diagnosis of liver cancer and hepatic hemangioma.
出处
《实用肿瘤杂志》
CAS
北大核心
1992年第3期139-142,共4页
Journal of Practical Oncology
关键词
铁蛋白
甲胎蛋白
AAT
肝肿瘤
ferritin alpha-1-antitrypsin alpha-fetoprotein liver cancer
