摘要
我国青年人大肠癌发病率明显地高于欧美国家,而且预后较差。本文用凝集素组化法比较了青年人和老年人Ⅲ期或Ⅳ期直肠癌原发灶及淋巴结转移灶四种凝集素受体表达状况。结果显示,青年组和老年组直肠癌原发灶及转移灶PNA,UEA-1、DBA和WGA受体呈分布不均一性。青年组直肠癌原发灶和(或)转移灶PNA受体阳性显著高于老年组。提示直肠癌在糖基化功能方面与组织形态异质性相似亦存在不均一性,青年人直肠癌PNA受体阳性高于老年人可能是青年人大肠癌生物学行为特征之一,同青年人直肠癌预后差可能有关。但有待于进一步研究。
The incidence of large-bowel cancer among the Chinese young people is higher than that of Western young men. The present study was designed to compare the status of four lectin-binding expressions of primary lesions (PL)/lymph node metastatic lesions (LML) of rectal cancer at stage Ⅲ or Ⅳ in the young (≤30 years) with those in the old (≥60 years) by the avidin-biotin-peroxidase technique. The heterogeneous expressions of PNA, UEA-1, DBA and WGA receptors of PL/LML of rectal cancers in the young and old groups were demonstrated. The positive results of PNA-binding was higher in the young group than in the old group, while the unreactive results of PNA-binding in PL/LML of the old group was significantly higher than that of the young group. The above results suggest that the heterogeneity of glycosylation in rectal cancer exists in the same way as histologic appearance. The higher PNA binding expression of rectal cancer in the young is probably related to their biological behavior character and poor prognosis, which remains to be further identified.
出处
《实用肿瘤杂志》
CAS
北大核心
1992年第3期146-148,共3页
Journal of Practical Oncology
关键词
肿瘤
直肠癌
转移
凝集素
neoplasm rectal cancer metastasis lectins
