摘要
本文描述了人血红细胞表面分子结构及其基因,介绍了有关血型转变的研究进展。从绿色咖啡豆中制备的α-半乳糖苷酶可以将B型血转变为O型血。体外研究证明了转型后的红细胞的完整性,正常活存率,呈现O型血的免疫特征。人Ⅰ期临床实验证明,转型后的B型红细胞可以安全地输给A型和O型血的自愿受试者。用mPEG包裹人血红细胞制备的通用型血,也能应用于临床输血。
This paper describes the molecular structure on the surface of human red blood celis as well as their coding genes. The paper also reviews the research advances in the field of blood conversion. The enzyme ot-galactosidase isolated from green coffee bean could convert the red blood celis of Blood group B into blood group O type. The experimental results in vitro conformed the integrity, normai viability of the converted red blood celis of blood group B, and showed that the converted celis exhibited immune response of blood group O type. Phase I clini-cal trials demonstrated that the converted red blood celis of blood group B could infuse safely to both blood group A and blood group O recipients. Chemical camouflage mPEG also converted the red blood celis into universal type for transfusion.
出处
《中国实验血液学杂志》
CAS
CSCD
1998年第2期91-97,共7页
Journal of Experimental Hematology
关键词
输血
血型
血型转变
Α-半乳糖苷酶
mPEG包裹
blood transfusion
blood group
blood group conversion
α-galactosidase, mPEG packing
