摘要
α 半乳糖苷酶 (α galactosidase ,α Gal,E .C .3.2 .1.2 2 )是广泛存在于自然界中的一种外切糖苷酶 ,传统上划分为两类异构酶 ,即α 半乳糖苷酶A和α 半乳糖苷酶B。在体内 ,α 半乳糖苷酶A水解以α 半乳糖残基为末端的糖复合物 ,而α 半乳糖苷酶B则水解以α N 乙酰 氨基半乳糖残基为末端的聚糖及糖蛋白、糖脂等复合物 ,因而它实际上是一种α N 乙酰 半乳糖胺酶。近年来 ,对于这两种异构酶的研究不断深入 ,并应用于人血型转换、异种器官移植及溶酶体贮积病的病理研究等方面 ,已展示出α
galactosidase (α-Gal) belongs to exoglycosidases, which distributed widely in the nature. α-Gal can be classified into two types: α-Gal A and α-Gal B. In vivo, α-Gal A is responsible for the cleavage of terminal α-galactosidic linkages in glycoconjungates; α-Gal B is an α-N-acetylgalactosaminidase in fact because it hydrolyses α-N-acetamidodeoxy-β-D-galactosidic residues from the terminals of a variety of complex carbohydrates and glycoconjugates. Now progress is being made of these two isoenzymes, including studies on blood group conversion, xenotransplantation of organ and pathophysiology of lysosomal storage diseases. There will be significant improvement in the future clinical application of α-Gal.
出处
《中国实验血液学杂志》
CAS
CSCD
2000年第3期236-239,共4页
Journal of Experimental Hematology
关键词
Α-半乳糖苷酶
血型转换
异种器官移植
输血
galactosidaseblood group conversionxenotransplantationlysosomal storage diseaseblood transfusion
