摘要
目的 :观察醒脑静注射液在小鼠急性有机磷农药中毒抢救的疗效。方法 :6 0只小鼠随机分为三组 ,A组腹腔注射生理盐水 ;B组腹腔注射阿托品 (1.5 m l/ 10 0 g)和解磷定 (0 .5 m l/ 10 0 g) ;C组腹腔注射阿托品 (1.5 m l/ 10 0 g)、解磷定 (0 .5 m l/ 10 0 g)和醒脑静注射液 (2 ml/ 10 0 g)。三组小鼠腹腔注射后分别用敌敌畏 (2 0 mg/ 10 0 g)灌胃中毒 ,计数其死亡数并取脑组织作病理检查。结果 :A组小鼠全死亡 ,B组小鼠死亡 8只 ,C组小鼠死亡 3只 ,C组小鼠存活率最高 ,明显优于 B组 (P <0 .0 5 )。脑组织病理检查 ,C组脑缺血、水肿等较 B组减轻。结论 :醒脑静注射液可明显减轻脑水肿 ,降低颅内压 ,改善有机磷农药中毒所致的神经系统症状 ,促进清醒 ,降低死亡率 。
Objective:To investigate therapeutic effects of Xingnaojing injection on acute organic phosphohorous poisoning in mice.Methods:Sixty healthy mice were randomly divided into 3 groups,group A(control);group B(abdominsl injected atropine 1.5ml/100g and pralidoxime 0.5ml/100g)and group C abdominsl injected atrapine 1.5ml/100g,pralidoxime 0.5ml/100g,Xingnao jing injection 2ml/100g).The three groups were given d.d.v.through gastric canal after abdomoinal inject ion and histopathological changes were observed.Results:All mice died in group A,8 mice died in group B and only 3 mice died in group C.The survival rates of group B and C were marked difference(P<0.05).The Xingnaojing treatment group markedly decreased pathological damage to brain tissue.Conclusions:Xingnaojing injection markedly inhibits brain tissue edema and can reduce the death rate of acute organic phosphorous poisoning.
出处
《黑龙江医药科学》
2003年第5期54-55,共2页
Heilongjiang Medicine and Pharmacy
关键词
醒脑静注射液
有机磷农药中毒
脑水肿
Xingnaojing injection
organic phosphorus poisoning
brain edema
