摘要
目的 :研究急性呼吸窘迫综合征 (ARDS)患者糖皮质激素受体 (GR)及皮质醇的变化 ,提出 ARDS患者糖皮质激素 (GC)的合理使用方案及其受体机制。方法 :研究综合性 ICU内 ARDS患者 ,采用放射配体结合测定法测定外周血白细胞 GR特异结合位点 ,并结合临床监测指标将患者分为轻、中、重 3型 ,提出的 GC使用方案在临床反复得到验证。结果 :根据 ARDS患者的 GR及内源性 GC(皮质醇 )水平使用 GC是合理的。结论 :个体化的 GC使用方案有利于提高 ARDS的救治成功率。
Objective: To study the change in glucocorticoid receptor(GR) and cortisol, for the purpose of proposing a rational use of glucocorticoid(GC) in patients with acute respiratory distress syndrome(ARDS), and to evaluate its receptor mechanism. Methods: ARDS patients in general ICU were enrolled for the study. GR of peripheral leukocytes in the patients were determined by radioligand binding assay using 〔3H〕 dexamethasone as ligand. ARDS patients were stratified into three groups, i.e. mild, moderate and severe by clinical indices. The dosage of GC in the treatment of ARDS varied according to the level of GR and clinical indices. Results: The proposed usage of GC according to the levels of GR, cotisol and clinical indices in the treatment of ARDS was shown to be rational. Conclusion: The therapeutic effect of individualized dosage of GC may be much better in the treatment of ARDS.
出处
《中国危重病急救医学》
CAS
CSCD
2003年第11期680-682,共3页
Chinese Critical Care Medicine
基金
国家自然科学基金资助项目 ( 3 973 0 2 10 )
关键词
急性呼吸窘迫综合征
受体机制
糖皮质激素受体
糖皮质激素
治疗
acute respiratory distress syndrome
receptor mechanism
glucocorticoid receptor
glucocorticoid
treatment
