摘要
目的 比较利培酮和氟哌啶醇治疗老年期精神障碍的疗效和安全性。方法 利培酮组22例,口服利培酮1.34±0.52mg/d;氟哌啶醇组20例,口服氟哌啶醇2.2±0.89mg/d,疗程均为8周。用临床疗效评定量表(CGI),简明精神症状检查量表(BPRS)、阴性症状评定量表(SANS)、汉密顿抑郁量表(HAMD)评价疗效。用药物副反应量表(TESS)评定不良反应。用简易智能量表(MMSE)评定对认知功能的影响。结果 临床总体疗效两组间无显著性差异(P>0.05),利培酮对BPRS各靶症状及阴性症状疗效显著,对阴性症状疗效优于氟哌啶醇(P<0.01),而且可提高MMSE的分值(P<0.01)。两组不良反应均以锥体外系症状和嗜睡为主。两组不良反应发生率无显著性差异(P>0.05)。结论 利培酮和氟哌啶醇对老年期精神障碍均有良好的疗效,利培酮对BPRS和SANS各常见靶症状疗效更显著,副反应小而安全,且不影响认知功能,更适宜于老年病人。
Objective To evaluate the efficacy and the safety of risperidone and haloperidal in treatment of senile mental disorder. Methods 22 patients had been given risperidone(1. 34 ± 0. 52mg · d)for 8wks, and 20 patients had been given haloperidal(22 ± 0. 89mg· d) for 8wks,They were all assessed by CGI, BPRS,HAMD,MMSE and TESS. Results The total efficacy showed no significantly difference between two groups(P>0. 05). Risporidone got a good response in all target symptoms of BPRS and negative symptoms . The efficacy for negative symptoms of Risperidon was better than that of Haloperidal ( P < 0. 01). The common side effects of two drugs included the extrapyramidal symptoms and drowsiness. There was no significant difference of side effects and incidence between two groups(P>0. 05). Conclusion Risperidone and Haloperidal have the same efficacy to senile mental disorder . Risperidone has better effect as target symptom of BPRS,SANS and less side effects for senile mental disorder. Not affecting the cognition function,Risperidone is more suitable to the senile patients.
出处
《山东精神医学》
2002年第4期203-205,共3页
Shangdong Archives of Psychiatry
