摘要
目的 :探讨氯氮平靶症状与血药浓度的关系。方法 :收集符合 CCMD- 2 - R精神分裂症诊断标准者 6 3例 ,入组时评定 PANSS量表。随后单服氯氮平达 2 8天 ,并在第 2 8天评定 PANSS,测定氯氮平血药浓度。结果 :4周末血药浓度范围 10 6～ 46 1μg/ L,血药浓度与 PANSS总分及诸因子分的减分率均无相关性 ,但 PANSS某些因子的显效率存在血药浓度治疗窗 ,阴性症状、无反应性、激越、抑郁、附加因子分的窗内显效率高于窗外。结论 :阳性症状的血药浓度治疗窗可能较宽 ;阴性症状和附和症状的血药浓度治疗窗较高 ,抑郁症状的血药浓度治疗窗较低 ,并对其机理作了相应的解释。
Objective:To study the relationship between efficiency of target symproms and serum clozapine level in schizophrenic patients with clozapine.Methods:Sixty-three patienis were diagnosed as schizophrenia according to CCMD-2-R.They were estimated with PANSS at treated 0 day,then treated with clozapine for twenty-eight days.They were again estimated with PANSS and measured serum clozapine level at treated 28th day.Results:The serum clozapine level were 106～461 μg/L at the end of fourth weeks.There was no significant difference between serum clozapine level and score reductive ratio of total PANSS score and of all factors.but some factor scores of PANSS existed therapeutic window of serum clozapine level.Clincal improred rate was higher within therapeutic window than without one in negative,no reactive,agitative,depressive and additional factor.Conclusions:Therapeutic window of serum clozapine level may be wider for positive symptoms.higher for negative and additional symptom and lower for depressive symptom.Their mechanisms have been explained. [
出处
《中国民政医学杂志》
2000年第5期257-258,261,共3页
Medical Journal of Chinese Civil Administration
关键词
氯氮平
血药浓度
精神分裂症
靶症状
Clozapine
Serum drug level
Schizophrenia
Target symptom
