摘要
目的：评价奎尼丁与胺碘酮治疗心房纤颤（房颤） 的临床特点及对心肌复极的影响。方法：回顾性分析３６ 例胺碘酮与１７ 例奎尼丁治疗房颤的转复率。短期防止复发的维持率及致恶性心律失常发生率，同时，观察其对ＱＴ间期，ＱＴ离散度的影响，并与阵发性房颤和健康对照组比较。结果：（１）奎尼丁组药物复律与胺碘酮组无差异，短期（１０ｄ） 防止复发率相近，但奎尼丁组２ 例发生致命性心律失常而胺碘酮无１ 例发生。（２） 阵发性房颤组与健康组ＱＴ间期和ＱＴ离散度无差异，奎尼丁和胺碘酮均延长ＱＴ间期和ＱＴＤ，但奎尼丁比胺碘酮影响更大。结论：（１） 奎尼丁和胺碘酮均可有效治疗房颤，但胺碘酮相对安全。（２）两者均延缓心肌复极并使复极离散。
AIM The purpose is to evaluate the therapeutic characteristics of quinidine and amiodarone and their effects on the myocardial repolarization in patients with atrial fibrillation.METHODS The 36 cases treated with quinidine and 17 ones with amiodarone are retrospectively analysed in their rates of conversion,recurrence,and proarrhythmia of atrial fibrillation.At the same time,their effects on the QT intermal and QT dispersion are compared.They are also compared with that of paroximal atrial fibrillation and health group.RESULTS (1)2 cases occurred lethal arrhythmia in quinidine group while no one in amiodarone group,although no difference in pharmacologic conversion and reocurrence of atrial fibrillation between the two groups.(2)No difference in QT internal and QT dispersion between paroximal atrial fibrillation and health group,however compared with the previous two groups,we found these parameter both significantly increase in quinidine and amiodarone groupes,especially in quinidine group,in which all index but QT increase greater than amiodarone group.CONCLUSION (1)Quinidine and amiodarone can control atrial fibrillation,but the later is safer.(2)Both of them prolong and diffuse myocardial repolarization,but the former is more severely.
出处
《解放军药学学报》
CAS
1999年第3期38-40,共3页
Pharmaceutical Journal of Chinese People's Liberation Army
