摘要
目的 探讨脂微球—前列腺素E1 (Lipo PGE1 )治疗多发伤后肝功能损害的临床疗效评价。方法 多发伤后肝功能损害 96例 ,随机分为两组 :对照组 4 9例 ,静脉滴注肌苷 1 0g,维生素C 2 0g,门冬氨酸钾镁 2 0ml1次 /d ,连续用 7d ;Lipo PGE1 治疗组 4 7例 ,在上述治疗的基础上加用Lipo PGE1 3ng (kg·min) ,持续 2h ,两次 /d ,连续 7d。同时监测肝功能指标谷丙转氨酶 (ALT) ,天冬氨酸转氨酶 (AST) ,总胆红素 (TBIL) ,总蛋白 (TP) ,总胆汁酸 (TBA) ,凝血酶原时间 (PT) ,部分凝血活酶时间 (APTT)。结果 Lipo PGE1 治疗组临床症状改善更明显 ,lipo PGE治疗组与对照组显效率分别为 5 1% (2 4 / 4 7)和 2 5 %(12 / 4 9) ,总有效率分别为 87% (4 1/ 4 7)和 74 % (36 / 4 9) ,两组比较差异有显著性意义 (P <0 0 5 )。结论 脂微球—前裂腺素E1 在多发伤后肝功能损害治疗中有重要的临床应用价值。
Objective To evaluate the clinical effects of Lipo-PGE 1 on the liver dysfunction after multiple trauam.Methods 96 patients with liver dysfunction after truama were randomly divided into control group and treatment group.The patients in control group received inoini 1.0 g,vitamin C 2.0 g,Kali magnesii aspartatis 20 ml every day through intravenous injection for 7 days.Besides these treaments,patients in the treatment group received and intravenous bolus of Lipo-PGE 1 3ng/(kg·min) for 2 h and one time every twelve hours for 7 days.The clinical and biochemical parameters were measured.Results Compared with control group,the clinical signs improved significantly in treatment group.The efficacy rate was higher in treatment group than in control group.Conclusion Lipo-PGE 1 has a sound efficacy in the improvement of clinical signs and hepatic functions in treating liver dysfunction after multiple trauma.
出处
《中华急诊医学杂志》
CAS
CSCD
2003年第11期762-764,共3页
Chinese Journal of Emergency Medicine
