摘要
目的 :观察PGE1 对肝移植术后早期移植物功能、肾功能、急性排斥反应及ICU停留时间的影响。方法 :40位患者在原位肝移植术后转入ICU ,随机分为对照组及治疗组 ,治疗组给予PGE140～60μg/h,两组患者均每天监测肝肾功能、胆汁排泄量 ,对比两组急性排斥反应和严重肾功能不全的发生率、ICU住院天数以及肝肾功能的变化。结果 :两组中肝功能的变化、急性排斥反应的发生率无明显差异 ;治疗组术后第3天、第5天的血BUN水平、第1、3、5天血Cr水平以及术后7d内Cr峰值水平均明显低于对照组 (P<0.05),治疗组发生严重肾衰竭需行血液净化治疗的患者的比率(10.0 %)低于对照组(26.3 %),但未显示有统计学差异(P=0.190) ,在ICU停留时间上 ,治疗组(7.4±4.8)d比对照组(10.4±4.5)d短 ,但统计学差异不明显(P=0.054)。结论 :在肝移植术后早期使用PGE1 可以对肾脏起到保护作用 ,相对的减少ICU停留时间 ,对移植物功能。
Objective: To investigate the impact of prostaglandin E1(PGE1)on early postoperative graft function?acute rejection and ICU length of stay after orthotopic live transplantation (OLT).Methods:Postoperation,40patients following OLT were transferred in of the intensive care unit(ICU).Patients were randomized to either receive PGE1 or control group,PGE1 was infusion by 40～60μg/h in treatment group.All patients of two groups were examinited liver and renal function,bile output every day,compared incidence of acute rejection and severe renal dysfunction,ICU length of stay,changes in liver and renal function.Results:Changes in liver and renal function and indence of acute rejection were not significantly different between two groupes in treatment group,BUN decreased significantly at the 3th and 5th day postoperation,Cr decreased significantly at 1th,3th,5th day and peak value during 7 days postoperative(P<0.05),incidence in treatment of severe renal failure needs for blood purification in treatment group(10.0%) was lower compared with control grope(26.3%), but there was not statististic difference(P=0.190),ICU length of stay was shorter in treatment group(7.42±4.8)d compared with control group(10.4±4.5)d,there was not statististic difference(P=0.054).Conclusion: PGE1 administration on early postoperation was resulted in protecting renal function,decreasing postoperative ICU length of stay relatively, but did not affect graft function and the incidence of acute rejection.
出处
《天津医科大学学报》
2001年第4期544-546,共3页
Journal of Tianjin Medical University
