摘要
目的 探讨老年糖尿病肾病 (DN)患者凝血、纤溶状态的特点。方法 2型糖尿病、DN男性患者 54例 :40～ 50岁 (ADN组 ) 2 4例 ,60～ 71岁 (ODN组 ) 30例 ;健康对照 36例 :40～ 50岁 (AC组 ) 1 7例 ,60～ 71岁 (OC组 ) 1 9例。检测凝血酶原片段 1 +2 (PF1 + 2 )、凝血酶 -抗凝血酶 复合物 (TAT)、纤维蛋白肽 A(FPA)、纤溶酶 -α2 纤溶酶抑制物复合物 (PIC)、D双聚体 (DD)及血栓调节蛋白 (TM)等凝血、纤溶指标。结果 (1 ) OC组较AC组 PF1 + 2 、FPA、PIC、DD、PAI- 1及 TM水平明显增加 ;(2 )与健康对照组相比 ,DN患者的 PF1 + 2 、TAT、FPA、PIC、DD、PAI- 1及 TM水平明显增加 ;(3)与 AND组相比 ,ODN组的 PF1 + 2 、TAT、FPA、PIC、DD和 TM水平无明显变化 ,但 PAI- 1水平明显增加。结论 DN患者存在明显的凝血活性亢进、并伴发纤溶活化 ,但老年 DN患者存在明显的纤溶抑制。
Objective To investigate the coagulation-fibrinolysis in aged men diabetic nephrophaty(DN) patiens.Methods Fifty-four male patients with type 2 diabetes mellitus complicated with DN were divided into 2 groups according to their age including 24 cases in ADN group(40~50 years old ) and 30 cases in ODN group (60~71 years old). Thirty-six healthy men mathed for age including17 cases in AC group ang 19 cases in OC group was used as the control group.We measured Prothrombin fragment1+2 (PF 1+2),thrombin-antithrombin 111 complex (TAT),fibrinopeptideA (FPA),plasmin-inhibitor complex (PIC), plasminogen activator inhibitor-1(PAI-1), D-dimer (DD) and thrombomodulin(TM),ect coagulation-fibrinolysis indices Results (1) In OC group, plasma PF 1+2, FPA, PIC, DD, PAI-1 and TM much higher than those in AC group. (2) Compared to the health control group, plasma PF 1+2, TAT, FPA, PIC, DD, PAI-1 and TM increased obviously in DN patients (3) Comopared to AND group, plasma PF 1+2, TAT, FPA, PIC, DD and TM in ODN group were similar. But plasma PAI-1 of ODN group was increased significantly.Conclusions DN patients have hypercoagulation and activity of fibrinolysis, but aged DN patients have evidently inhibition on fibrinolysis.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2003年第11期738-740,共3页
Chinese Journal of Gerontology
