摘要
目的探讨妊娠滋养细胞疾病中抑癌基因PTEN的表达与葡萄胎恶变的关系。方法采用免疫组织化学 (SP)法检测正常绒毛 15例、未恶变的葡萄胎 30例、恶变的葡萄胎及绒癌 2 5例中PTEN的表达情况。结果正常绒毛组PTEN阳性表达率为 93.3%,显著高于葡萄胎组的 34 .5 %(19/ 5 5 ) ,非恶变组PTEN的阳性表达率显著高于恶变组 (P <0 .0 1) ;恶变组恶变前后相比较 ,恶变后PTEN表达率显著降低 (P <0 .0 1) ;侵蚀性葡萄胎及绒癌之间PTEN的表达差异无显著意义 (P >0 .0 5 )。结论PTEN表达下降与葡萄胎恶变有关 ,PTEN的表达可望成为预测葡萄胎恶变的一项参考指标。
ObjectivesTo explore the relation between expression of oncogene suppressor PTEN gene in gestational trophoblastic diseases and malignant change of hydatidiform mole (HM).MethodsThe expressions of PTEN gene in specimens from 15 cases of normal chorionic villi, 30 cases with non-malignant HM and 25 cases with malignant HM and choriocarcinoma were detected by immunohistochemical SP method.ResultsThe positive expression rate of PTEN gene in normal villi group was significantly higher than that in HM group [93.3% vs 34.5%(19/55)](P<0.01). The positive expression rate of PTEN gene in group of non-malignant HM was obviously higher than that in group of malignant HM (P<0.01); whereas the positive expression rate of PTEN gene decreased significantly after occurrence of malignancy as compared with that before malignancy (P<0.01). No significant difference in expression of PTEN gene was found between invasive HM and choriocarcinoma (P>0.05). ConclusionThe decreased expression of PTEN gene is closely related to the malignant change of HM, its expression can serve as one of referential markers for forecasting of HM turning to malignancy.
出处
《医学临床研究》
CAS
2003年第10期762-763,共2页
Journal of Clinical Research
