摘要
目的 介绍转化生长因子 β(TGF β)及其与移植排斥的关系。 方法 复习近年相关文献并加以综述。结果 TGF β的免疫抑制作用可对抗移植器官在移植术早期遭受的排斥损伤 ;同时TGF β能促进成纤维细胞分化 ,增加胶原生成 ,抑制胶原酶活性而降低胶原的分解 ,促进基质沉淀 ,引起移植器官纤维化及动脉粥样硬化 ,TGF β的基因多态性与此密切相关。此外 ,缺血再灌注损伤、免疫抑制剂亦对TGF β的合成产生影响。 结论 TGF β是一种具有多向性和多种功能的细胞因子 ,与急。
Objective To introduce transforming growth factor β(TGF β) and the relationship between TGF β and graft rejection. Methods Relevent articles in recent years were reviewed.Results The immunodepressive function of TGF β could resist transplant organ rejection injury in early postoperative period ; meanwhile TGF β also caused fibroblast migration and promoted matrix deposition by increasing collagen production and decreasing collagen breakdown via inhibition of collagenases,which resulted in transplant organ fibrosis and arteriosclerosis, gene polymorphisms of the TGF β were associated with it. Moreover,ischemia reperfusion injury and immunodepressive drug also affected production of TGF β.Conclusion TGF β as a pleiotropic and multifunctional cytokine contributes to the development of acute and chronic rejection.
出处
《中国普外基础与临床杂志》
CAS
2003年第2期179-181,共3页
Chinese Journal of Bases and Clinics In General Surgery
