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蛋白酶活化受体-2的研究进展 被引量:8

Proteinase-activated receptor-2 and inflammation in respiratory tract
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摘要 蛋白酶活化受体 (protease activatedreceptors,PARs)属于G蛋白偶联受体家族成员 ,其N 末端被蛋白酶裂解后 ,可形成新的N 末端。新N 末端能够结合、激活自身受体。PAR 2是PARs的成员之一 ,其激活、灭活、脱敏、复敏、及其与信号转导途径的关系 ,尤其是与疾病 (如呼吸道慢性炎症 )
出处 《生理科学进展》 CAS CSCD 北大核心 2003年第4期373-375,共3页 Progress in Physiological Sciences
基金 国家自然科学基金资助课题 (30 14 0 0 2 3)
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参考文献7

  • 1Macfarlane SR, Seatter M J, Kanke T, et al. Proteinase-activated receptors. Pharmacol Rev, 2001,53 : 245 - 282.
  • 2Sun G, Stacey MA, Schmidt M, et al. Interaction of mite allergens Der p3 and Der p9 with protease-activated receptor-2 expressed by lung epithelial cells. J Immunol,2001,167 :1014 -1021.
  • 3Dery O, Thoma MS, Wong H, et al. Trafficking of proteinase-activated receptor-2 and beta-arrestin-1 tagged with green fluorescent protein. Beta-arrestin-dependent endocytosis of a proteinase receptor. J Biol Chem, 1999,274 : 18524 -18535.
  • 4DeFea KA, Zalevsky J, Thoma MS, et al. Beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2. J CellBiol,2000,148 : 1267 - 1281.
  • 5Asokananthan N, Graham PT, Fink J, et al. Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial ceils. J Immunol, 2002,168 :3577 - 3585.
  • 6Chambers LS, Black JL,Poronnik P,et al. Functional effects of protease-activated receptor-2 stimulation on human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol, 2001,281 : L1369 - L1378.
  • 7Akers IA, Parsons M, Hill MR, et al. Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2. Am J Physiol Lung Cell Mol Physiol, 2000,278 : L193 - L201.

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