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化疗后肺鳞癌组织中细胞胀亡和凋亡检测 被引量：1

Detection of oncosis and apoptosis in pulmonary squamous cell carcinoma tissue after preoperative chemical therapy
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摘要 目的 :检测化疗后肺鳞癌组织中细胞胀亡和凋亡情况。方法 :收集 1 6例接受术前新辅助化疗的手术切除肺鳞癌标本 ,利用透射电镜、TUNEL及免疫组织化学技术检测其中胀亡、凋亡细胞及微血管密度 (MVD)测定 ,并与 8例非化疗者进行对照分析。结果 :化疗组肺癌组织内胀亡细胞及凋亡细胞均明显多于非化疗组 ,MVD则明显缺乏。化疗组中MVD高表达者OI低于低表达者 ,而AI则高于低表达者。结论 :肺鳞癌的辅助化疗可诱导肿瘤细胞发生胀亡和凋亡。 Aim: To explore if chemotherapy (CH) induces oncosis and/or apoptosis in pulmonary squamous cell carcinoma. Methods: By using transmission electron microscope, TUNEL, and immunohistochemical technique, oncosis, apoptosis, and microvessel density (MVD) in 16 cases of pulmonary squamous cell carcinoma, which had chemotherapy before surgery were studied. Results: More oncosis and apoptosis cells were observed in the group receiving CH than those without, but MVD was lower in the previous group. Apoptosis index (AI) was higher while oncosis index (OI) was lower in MVD high-expressed group than those in MVD low-expressed group. Conclusion: CH may induce oncosis and apoptosis in pulmonary squamous cell carcinoma.
作者 赵高峰 僧靖静 刘文超 高冬玲 马继红 孟红印 韩立志 田川 胡伟 付明倜 屈清荣 张云汉 李胜云
机构地区 郑州大学第一附属医院外科 郸城县人民医院外科 郑州大学第一附属医院病理科 夏邑县公疗医院外科 沈丘县人民医院外科
出处 《郑州大学学报（医学版）》 CAS 北大核心 2003年第6期862-864,共3页 Journal of Zhengzhou University(Medical Sciences)
基金 河南省杰出青年科学基金资助项目 0 3 12 0 0 2 3 0 0
关键词 肺肿瘤 鳞状细胞癌 胀亡 凋亡 化学治疗 微血管密度 pulmonary neoplasm squamous cell carcinoma oncosis apoptosis chemical therapy microvessel density
分类号 R765.3 [医药卫生—耳鼻咽喉科]
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参考文献10

  • 1赵高峰,僧靖静,鲁显浩,高冬玲,田川,王善磊,刘文超,付明倜,马继红,屈清荣,赵松,张云汉.食管鳞状细胞癌组织中细胞胀亡及微血管密度检测[J].郑州大学学报（医学版）,2003,38(6):851-854. 被引量：7
  • 2赵高峰,僧靖静,卫战文,田川,高冬玲,陈奎生,马长路,李全荣,齐宇,马继红,屈清荣,张云汉.食管鳞状细胞癌组织中细胞胀亡与凋亡检测[J].郑州大学学报（医学版）,2003,38(6):854-857. 被引量：5
  • 3Trump BF, Berezesky ZK, Chang SH, et al. The pathways of cell death : oneosis, apoptosis, and necrosis. Toxieol Pathol,1997, 25(1): 82.
  • 4Crisby M, Kallin B,Thyberg J,et al. Cell death in human atherosclerotic plaques involves both oncosis and apoptosis. Atherosclerosis, 1997, 130(1-2):17.
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二级参考文献13

  • 1Trump BF, Berezesky ZK,Chang SH,et al. The pathways of cell death : oneosis, apoptosis, and necrosis. Toxieol Pathol,1997, 25(1): 82.
  • 2Fernandez-prada CM, Hoover DL, Tall BD, et al. Human monocyte-derived macrophages infected with virulent Shigella flexneri in vitro undergo a rapid cytolytic event similar to oncosis but not apoptosis. Infect Immun, 1997, 65 (4) : 1 486.
  • 3Saraste A. Morphologic criteria and detection of apoptosis. Herz, 1999,24(3): 189.
  • 4Crisby M,Kallin B,Thyberg J, et al. Cell death in human atherosclerotic plaques involves both oncosis and apoptosis. Atherosclerosis, 1997, 130(1-2): 17.
  • 5Zhang C,Xu Y, Gu J, et al. A cell surface receptor defined by a mAb mediates a unique type of cell death similar to oncosis. Proc Nail Acad Sci USA, 1998, 95(11) : 6 290.
  • 6Walisser JA,Thies RL. Poly (ADP-ribose) polymerase inhibition in oxidant-stressed endothelial cells prevents oncosis and permits caspase activation and apoptosis. Exp Cell Res,1999. 251(2) : 401.
  • 7Hayakaw Y,Takemura G, Misao J,et al. Apoptosis and overexpression of bax protein and bax mRNA in smooth muscle cells within intimal hyperplasia of human radial arteries : analysis with arteriovenous fistulas used for hemodialysis. Arterioscler Thromb Vasc Biol, 1999, 19(9) : 2 066.
  • 8Shirai T. Commentary: oncosis and apoptosis: two faces of necrosis in a new proposal to clear up the confusion regarding cell death. Toxicol Pathol, 1999, 27(4) : 495.
  • 9Mallat Z, Tedgui A. Apoptosis in the vasculature: mechanisms and functional importance. Br J Pharmacol, 2000, 130(5) : 947.
  • 10Kunishima A ,Takemura G,Takatsu H ,et al. Mode and role of cell death during progression of atherosclerotic lesions in hypercholesterolemic rabbits. Heart Vessels, 1999, 14 (6) :295.

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郑州大学学报（医学版）
2003年 第6期

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