摘要
目的 应用中药血清药理学方法 ,观察玉屏风散对小鼠白细胞活化功能的影响。方法 9组小鼠按0 .1ml/ 10g体重用玉屏风散水煎液灌胃 ,剂量相当于 48.0g饮片 /kg体重 ,于给药后 15min、30min、1h、1.5h、2h、2 .5h、3h、4h分别在无菌条件下取血 ,分离血清进行白细胞活化作用检测。另设蒸馏水灌胃后的空白血清作对照组。结果 30～ 12 0min的含药血清对小鼠白细胞均具有活化作用 (P <0 .0 1或P <0 .0 5 ) ,尤以 1h作用最强。结论 时 效关系研究表明 ,玉屏风散煎剂 48.0 g /kg体重灌胃后 30～ 12 0min时相的含药血清 ,对白细胞具有不同程度的活化作用。
Objective Using a method of serum pharmacology, the effect of Yu Ping Feng Pulvis (YPFP) on the activity of WBC was studied in mice. Method 9 groups of healthy mice were ingested YPFP apozem at a dose equivalent to 48.0g herbal slices per kilogram weight . Their blood were collected in an aseptic state to disaffiliate serum at different times when the activity of WBC was investigated. One more group was ingested distilled water, whose extracted serum was used as a control. Results Drug-containing serum taken at the time of 30～120min after ingestion could evidently stimulate the activity of WBC (P<0.01 or P<0.05), and drug-containing serum taken at 1h exerted the most obvious effect. Conclusion The drug-containing serum of mice taken at the time of 30～120min after ingesting YPFP apozem could improve the activity of WBC in varied degrees in terms of time-effect relationship. =
出处
《皖南医学院学报》
CAS
2001年第4期251-252,255,共3页
Journal of Wannan Medical College
关键词
玉屏风散
小鼠
白细胞活化
血清药理学
中药
serum pharmacology
Yu Ping Feng Pulvis
time effect relationship
activity of WBC
