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EGFR和C-erbB2在非小细胞肺癌中的表达及研究前景 被引量：3

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摘要 肺癌的发生和发展是一个多因素多阶段的过程 ,表现为癌基因、抑癌基因、肿瘤转移相关基因的点突变、扩增、异位和缺失 ,以及某些抗原分子的异常表达。表皮生长因子受体 (EGFR)和C erbB 2癌基因在非小细胞肺癌中过表达并与肿瘤的生长转移及患者的预后密切相关 ,但在小细胞肺癌中未发现过表达。本文综述了EGFR和C erbB2的结构、功能、同源性及在正常组织中的分布 ,重点讨论了EGFR和C erbB2在非小细胞肺癌 (NSCLC)发生发展中的作用及在NSCLC的诊断、治疗。
作者 李新举 庄鹏晖 梁景仁
机构地区 西安交通大学第一医院
出处 《陕西肿瘤医学》 CAS 2001年第4期292-293,共2页 ShanXi Oncology Medicine
关键词 非小细胞肺癌 表皮生长因子受体 C-ERBB2 基因表达
分类号 R734.2 [医药卫生—肿瘤]
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参考文献19

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同被引文献28

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二级引证文献19

陕西肿瘤医学
2001年 第4期

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