摘要
目的 :研究周围型肺腺癌和鳞癌的CT征象、病理分级与c erbB 2蛋白异常表达的关系。方法 :6 2例经手术、病理证实的周围型肺腺癌、鳞癌术前CT扫描 ,并运用免疫组织化学技术ABC法对手术切除标本进行c erbB 2蛋白检测。将检测结果与肿瘤的CT征象、病理分级进行比较 ,对统计数字进行卡方检验。结果 :①腺癌c erbB 2蛋白的过度表达高于鳞癌 (P <0 .0 5 )。②分化程度低、有肺门和 /或纵隔淋巴结转移者c erbB 2蛋白的过度表达率明显增高 (P <0 .0 5 ,P <0 0 1)。③具有棘突征、血管连接征的周围型肺腺癌和鳞癌c erbB 2蛋白过度表达率明显高于无以上征象者 ;而瘤体最大直径 >3cm的腺癌高于瘤体最大直径≤ 3cm的腺癌。④肿瘤强化明显者 ,其c erbB 2蛋白过度表达率增高 (P <0 .0 5 )。结论 :周围型肺癌c erbB 2蛋白的过度表达与组织学类型及CT表现有关 。
Objective:To study the correlation between CT appearances,pathologic grade and c erbB 2 protein abnormal expression in peripheral lung adenocarcinoma and squamous cell carcinoma.Methods:62 cases of peripheral lung adenocarcinoma and squamous cell carcinoma were confirmed by operation and pathology were examined with CT before operation. The expression of c erbB 2 protein was assessed immunohistochemically with the avidin biotin peroxidase complex technique,the examination results were compared with CT appearances and pathologic grade of the tumors,and the data were statistically analyzed using chi square test.Results:①The expression of c erbB 2 protein was higher in adenocarcinoma than that in squamous cell carcinoma.②In poorly differentiated and lymph node metastasis group,c erbB 2 protem expression increased significantly.③Peripheral lung adenocarcinoma and squamous cell carcinoma with spinous process and vessel convergency had higher expression of c erbB 2 protein, and the peripheral lung adenocarcinoma with diameter over 3cm also had higher expression of c erbB 2 protein.④The expression of c erbB 2 was higher in lung carcinomas with obvious contrast enhancement(>41HU).Conclusion:The expression of c erbB 2 protein is correlated with histologic pattern and CT appearances of lung cancer. Some CT appearances can indicate the biological behavior of peripheral lung carcinoma.
出处
《医学影像学杂志》
2002年第4期235-239,共5页
Journal of Medical Imaging
