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3,5-二叔丁基-4-羟基苯甲酸的合成 被引量：4

Synthesis of 3,5-Di-tert-butyl-4-hydroxybenzoic Acid
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摘要 以 2 ,6 -二叔丁基 - 4 -甲基苯酚为原料 ,在乙酸溶液中与溴反应形成 3,5 -二叔丁基 - 4 -羟基苯甲醛 ,然后经 Jones氧化得到 3,5 -二叔丁基 - 4 -羟基苯甲酸 ,总收率 6 3.7%。 3,5-Di- tert -butyl-4-hydroxybenzoic acid was synthesized in 63.7% overall yield by treatment of 2,6-di- tert -butyl-4-methylphenol with bromine in acetic acid to give 3,5-di- tert -butyl-4-hydroxy- benzaldehyde which underwent oxidization by Jones reagent.
作者 赖宜生 张奕华 李月珍
机构地区 中国药科大学新药研究中心 南宁地区教育学院化学系
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2003年第11期546-547,共2页 Chinese Journal of Pharmaceuticals
关键词 3 5-二叔丁基-4-羟基苯甲酸 2 6-二叔丁基-4-甲基苯酚 3 5-二叔丁基-4-羟基苯甲醛 中间体 合成 3,5-di- tert -butyl-4-hydroxybenzoic acid 2,6-di- tert -butyl-4-methylphenol 3,5-di- tert -butyl-4-hydroxybenzaldehyde intermediate synthesis
分类号 O622.5 [理学—有机化学]
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参考文献8

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同被引文献28

  • 1王俊,杨洪军,李翠勤.受阻酚类抗氧剂的研究进展[J].化学与生物工程,2005,22(8):10-12. 被引量：49
  • 2Xu ZB,Guo ZR.Advances in research and bioactivities of compounds containing di-tert-butylphol[J].Yaoxue xuebao,2001,36(11):877-880
  • 3Vachy R.Antiviral use of a 2,6-di-tert-butylphol compounds substituted in position 4,particularly in relation to herpesviruses and papillom aviruses[P].WO 9208450,1992 -05 -29
  • 4Unangst PC,Connor DT,Cetenko WA,et al.Synthesis and biological evaluation of 5-[[3,5 -bis(1,1 -dimethylethyl) -4-hydroxyphenyl]methylene]oxazoles,and-imidazoles:novel dual 5-lipoxygenase and cyclooxygenase inhibitors with anti in flam matory activity[J].J Med Chem,1994,37(2):322-328
  • 5Spivacj John D,Klemchuk,et al.Lingt stabilized polyolefin compositions(P].US 3839277,1974-10 -01
  • 6Dibattisto,Anthony D,Spivacj John D.Stabilizer system of metal hydroxyalkyl phosphonic acid,UV absorber and benzoate[P].US 3901848,1978 -04 -26
  • 7Mathis Ronaldd.UV -stabilizing system for polymeric materials comprising phenyl benzoate and nikel or cobalt complexes of partially fluorinated β-diketone[P].US 3838099,1974 -09 -24
  • 8B T Waiton,et al.Pesti.Biochem and Physi.1979,12:23-30
  • 9Coppinger G M,Campbell T W.Reaction between 2,6-di-butylp -cresol and bromine (J).J Am Chem Soc,1953,75(2):734-736
  • 10Xu ZB,Guo ZR.Advances in research and bioactivities of compounds containing di-tert-butylphol[J].Yaoxue xuebao,2001,36 (11):877-880.

引证文献4

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中国医药工业杂志
2003年 第11期

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