摘要
利用从椰毒假单胞菌(Pseudomona cocovenenans)中所分离提取的毒黄素(toxoflavin)对黄嘌呤氧化酶(EC.1、2 3、2)作用的动力学试验表明,毒黄素是此酶的非必需激活剂,而且对以次黄嘌呤为底物的反应的激活作用明显高于以黄嘌呤为底物的反应。此激活作用属于部分混合型。这一结果为探寻毒黄素对人体的致毒机理提供了一条重要线索。
The kinetic studies of effect of toxoflavine on the action of xanthine oxidase (ECl, 2,3,2) which was extracted from Pseudomona cocovenenans showed that toxoflavin was nonessential activator for the enzyme, and the activation in condition of hypoxanthine as substrate was more marked than xanthine. The activation obeyed the partial activation type. These results provide us a clue for searching toxic mechanism of toxoflavin for human.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
1992年第2期119-122,共4页
Progress In Biochemistry and Biophysics
关键词
黄嘌呤氧化酶
毒黄素
toxoflavin, xanthine oxidase, partial activation
