摘要
目的 :研究血管内皮生长因子在创伤及修复过程中的表达变化。方法 :用免疫组织化学技术和图像分析技术 ,对实验大鼠生前及死后不同损伤时间损伤的皮肤创缘组织中血管内皮生长因子的表达变化。结果 :生前损伤组血管内皮生长因子在上皮细胞的表达于损伤后 12h即开始增强 ,其中以 2 4～ 48h表达最强。 2 4～ 48h血管内皮生长因子除了上皮细胞的表达外 ,在巨噬细胞及新生毛细血管内皮细胞浆内呈强阳性表达。死后损伤组不同时相均无任何表达。结论
Objective: To explore the expression change of vascular endothelial growth factor during the healing process of rats skin wound. Methods: Immunohistochemical and image-analysis methods were performed on vital skin wounds and post mortem damage. Results: The expression of the vascular endo thelial growth facto r in epithelial cells was already enhanced since 12 h after damage and their str ongest expression reaction was seen at 24～48 h. In addition, the expression of v ascular endothelial growth factor was also found in the macrophages and the plas ma of endothelial cells of new-formed capillaries at 24～48h. No any expression changes was found in the postmortem damage. Conclusion: It s uggested that the en dogenous vascular endothelial growth factor played an important role in the cour se of the wound healing.
出处
《江苏大学学报（医学版）》
CAS
2003年第5期421-422,424,共3页
Journal of Jiangsu University：Medicine Edition
基金
镇江市科学技术局基金资助 (NO .SH2 0 0 2 0 4 1 )
