摘要
目的 :比较帕罗西汀与阿米替林治疗帕金森氏病伴发抑郁的疗效及不良反应。方法 :5 6例帕金森氏病伴发抑郁病人 ,随机分 2组 ,帕罗西汀组 2 8例 ,每天给帕罗西汀 2 0mg ,4w为一个疗程。阿米替林组 2 8例 ,每天给阿米替林 10 0～ 15 0mg ,4w为一个疗程。采用汉密顿抑郁量表 (HAMD) ,药物副反应量表 (TESS)分别评定。 结果 :帕罗西汀组 :痊愈 2 0例 (71 4 3% ) ,显进 4例 (14 2 9% ) ,进步 2例 (7 14 % ) ,无效 2例 (7 14 % ) ;有效率 (痊愈 +显进 +进步 ) 92 86 % ;阿米替林组 17例 (6 0 71% ) ,显进 5例 (18 5 6 % ) ,进步 3例 (10 71% ) ,无效 3例 (10 71% ) ,有效率 89 2 9%。两组有效率差异无显著性 (χ2 =0 2 2 ,P >0 0 5 )。帕罗西汀组TESS评分为 1 4 4± 2 38,而阿米替林组TESS评分为 3 4 1± 2 76 ,明显高于帕罗西汀组 ,差异有非常显著意义 (t =2 86 ,P <0 0 1)。阿米替林组不良反应较多 ,如 :口干、便秘、视物模糊等。结论 :帕罗西汀治疗帕金森氏病伴发的抑郁疗效与阿米替林相当且副作用少。
Objective:To study clinical efficacy and safety of paroxetine and amitriptyline in the Parkinson's disease(PD) with depression.Methods:Fifty-six PD with depression patients were randomly divided into two groups:paroxetine group of 28 patients(male:21 and female:7;age:58.87±11.85)were treated with paroxetine 20mg/d,po,pd for four weeks.Amitriptyline group of 28 patients(male:23 and female:5;age 53.93±10.36)were treated with amitriptyline 100～150mg/d,po,bid for four weeks.Results:The total clinical effective rates were 92.86% for paroxetine group,89.29% for amitriptyline (P >0.05).The adverse reactions in the paroxetine group were less than that in amitriptyline group.Conclusion:Paroxetine shows same effective and less side-effects in treating PD with depression compared to amitriptyline.
出处
《中国民康医学》
2003年第11期657-658,共2页
Medical Journal of Chinese People’s Health
