摘要
从人参(Panax ginseng C.A.Meyer)芦头中分离得到10个化合物。经理化性质、波谱分析和薄层析分别鉴定为:20(R)-人参皂甙-Rh_1(Ⅰ),人参皂甙-Rg_3(Ⅱ),20(S)-人参皂甙-Rg_2(Ⅲ),-Rg_1(Ⅳ),-B(Ⅴ),-Rd(Ⅵ),-Rc(Ⅶ),-Rb_2(Ⅷ),-Rb_1(Ⅸ),-Ro(Ⅹ).其中化合物Ⅰ,Ⅱ为首次从人参芦头中分离得到的已知成分,并对其中9种主要人参皂甙进行了抗氯化钡诱发大白鼠心律失常作用的研究。
Ten compounds were isolated from the rhizomes of Panax ginseng C.A. Meyer and identified as 20(R)-ginsenoside-Rh_1 (1), ginsenoside-Rg_3(2),-Rg_2(3), -Rg_1(4), -B(5), -Rd(6), -Rc(7), -Rb_2(8), -Rb(9) and -Ro (10). The compounds(1) and (2) were for the first time isolated from the rhizomes of the title plant. Nine of the ten ginsenosides obtained were shown to have antiarrhythmic activity.
关键词
人参
人参皂甙
抗心律失常
Panax Ginseng C. A. Meyer
Ginsenosides
Antiarrhythmic activity
