摘要
目的:探讨原发性高血压(EH)患者血清胰岛素样生长因子-1(IGF-1)水平的变化,评价IGF-1对EH及其并发症左室肥厚(LVH)的病理生理意义。方法:用特异性放射免疫法测定50例EH患者(EH组)和25例正常人(正常对照组)的血清IGF-1水平。结果;EH患者血清IGF-1水平明显高于正常对照组(P<0.01),EH并发LVH患者乎均血清IGF-1水平明显高于无LVH者(P<0.01)。结论:EH患者尤其是伴发LVH者血清IGF-1水平升高,提示IGF-1可能参与EH及其并发症LVH的形成。
Objective: To investigate the changes of serum insulin-like growth factor-1 (IGF-1) levels in patients with essential hypertension (EH) and assess the pathophysiologic significance of IGF-1 in hypertension patients with left ventricular hypertrophy (LVH) . Methods: Serum IGF-1 levels were measured by specific radioimmunoassay in 50 EH patients and in 25 normotensive controls. Results: The results showed that serum IGF-1 level were higher in EH than normal controls (12. 86 ± 3. 67 vs 9. 67±2. 57, P<0. 01) . The IGF-1 Serum level were higher in EH with LVH than in those without LVH (14. 15 ± 4. 23 vs 11. 57 ± 3. 10, P<0. 01) . Conclusion: These results indicate that serum IGF-1 levels are increased in essential hypertension, especially in EH with LVH.It also suggest that IGF-1 may involve hypertension and hypertensive cardiac hypertrophy.
出处
《心血管康复医学杂志》
CAS
2003年第5期400-402,共3页
Chinese Journal of Cardiovascular Rehabilitation Medicine
