摘要
目的 探讨孕期中药治疗对巨细胞病毒(CMV)活动性感染孕妇子代生长发育的影响。方法 1996年1月至2002年6月,采用前瞻性随机对照研究方法,从有异常妊娠史的孕妇中筛查出CMV活动性感染孕妇240例,随机分组。观察组122例给予中药治疗,对照组118例不给予治疗,比较两组孕妇转阴率、胎盘和胎儿感染率以及子代生长发育情况。结果 观察组孕妇CMV IgM和CMV nRNA转阴率77.05％(94/122)、胎盘感染率48.98％(48/98)、宫内传播率21.74％(10/46),对照组分别为38.14％(45/118)、67.50％(54/80)和52.63％(20/38),两组差异均具有统计学意义(P均<0.01)。观察组子代出生时35例正常,11例异常;对照组20例正常,18例异常(P<0.01)。观察组6月龄婴儿智力发育指数和精神运动发育指数均高于对照组,但差异无统计学意义(P>0.05)。结论 孕期中药治疗在改善CMV活动性感染孕妇子代生长发育方面具有一定的意义。
Objective To study the effects of the traditional Chinese medicine(TCM)for mothers with cytomegalovirus active infection on fetal growth and development. Methods The prospective randomized controlled trials were done dur-ing January 1996 to June 2002. From the pregnant women with an abnormal pregnant history,240 were screened to be with active cytomegalovirus(CMV) infection by ELISA and RT-PCR. They were randomized tnto two groups. In the observation group, 122 cases were administered with Jinyebaidu granule(TCM), while the other 118 cases (control group) did not have any medicine. Results The negative-turning rate of cytomegalovirus IgM and cytomegalovirus mR-NA in the control and observation group was 38.14% (45/118) and 77.05% (94/122) ,respectively( P <0.01); the placentai infection rate was 67.50% (54/80) and 48.98% (48/98) ,respectively( P <0.01) ,and the intrauterine infection rate was 52.63%(20/38) and 21.74%(10/46),respectively( P <0.01).Totally 35 normai infantsand 11 abnormal infants were born in the treated group;20 normai and 18 abnormal infants were born in the control group( P < 0.01) .Conclusion To treat cvtomegalovirus actively infected pregnant women with TCM is beneficial to fetal growth and development.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
2003年第10期609-611,共3页
Chinese Journal of Practical Gynecology and Obstetrics
基金
国家"九五"科技攻关项目(项目编号:96-904-06-08)
