摘要
目的探讨先天性无症状巨细胞病毒（ＨＣＭＶ）感染患儿的近期生长发育情况，评价头颅Ｂ超和脑干听觉诱发电位（ＡＢＲｓ）在早期监测病情中的作用。方法对２４例感染婴儿及１３例对照婴儿进行了为期一年的前瞻性随访。检查内容包括体格测量、Ｂａｙｌｅｙ婴幼儿发育量表、头颅Ｂ超和ＡＢＲｓ等。结果感染组婴儿体格、智力发育迟缓率与对照组相比，差异无显著意义；感染组出生及３个月时的头颅Ｂ超异常率均高于对照组，差异有显著意义（Ｐ＝０．０１１，Ｐ＝０．０３２）；１２个月时的头颅Ｂ超异常率虽高于对照组，但差异无显著意义。主要异常表现有颅内出血、神经胶质反应、室管膜下囊肿等。感染组ＡＢＲｓ的异常率高于对照组，差异有显著意义（Ｐ＝０．００３）。结论先天性ＨＣＭＶ感染对新生儿及婴儿的神经系统发育可造成一定的不良影响，有必要加强头颅Ｂ超和ＡＢＲｓ的早期监测，以便尽早采取干预措施。
Objective To assess the role of neurosonographic imaging and auditory brainstem responses (ABRs) in early detection of the disorders in growth and neurodevelopment of infants with asymptomatic congenital HCMV infections. Methods Twenty four infected newborn infants and 13 control infants were followed up prospectively for one year. Physical growth, Bayley developmental scale, neurosonographic and audiologic examination were used to identify the sequelae of HCMV infections. Results No difference between groups were noted on physical growth and mental development. However, significant differences were observed on abnormal neurosonographic findings in infants at 12 months of age, but not at birth and at 3 months of age between groups. Three main abnormal findings were intracranial hemorrages, glial reaction and subependymal cysts. The numbers of infants with sensorineuronal hearing loss were significantly higher in infected group than in control group ( P =0 003).Conclusion These data suggest that asymptomatic congenital HCMV infections may be associated with a broad range of subtle neurosonographic and audiologic impairments during early infancy. Neur osonographic imaging and ABRs are useful in the evaluation of the infants with asymptomatic congenital HCMV infections.
出处
《中华儿科杂志》
CAS
CSCD
北大核心
1998年第1期37-39,共3页
Chinese Journal of Pediatrics
基金
国家八五攻关课题
上海市科委资助
关键词
巨细胞病毒感染
精神发育迟滞
听觉丧生
Cytomegalovirus infections Mental retardation Hearing loss, sensorineural
