摘要
目的 探讨大黄治疗肝硬化腹水的疗效及机制。方法 3 8例乙型肝炎后肝硬化腹水患者给予大黄治疗 ,并与双氢克尿噻单用及联用疗效对比 ,疗程 2 1d ,检测肝功、肿瘤坏死因子 -α(TNF -α)、内毒素、一氧化氮的变化。结果 经大黄治疗后 ,腹水明显减轻 ,肝功、TNF -α、内毒素、一氧化氮的水平明显下降 ,与双氢克尿噻联用效果更好。结论 大黄有改善肝功、消肿、利水等作用 ,与血清中TNF -α、内毒素。
Objective\ To research the effects of rhubarb in treating live cirrhosis patients with ascites.Methods\ 38 live cirrhosis patients with ascites were treated with rhubarb, meanwhile the comparisons of effect between rhubarb group,hydrochlorothiazide group and combination group. Measure of serum liver function,TNF-α,endotoxin, nitric oxide(NO) were performed before and after the therapy.Results\ Patients′ symptom were better and serum liver function,TNF-α, endotoxin endotoxin,NO were significantly decreased after treated with rhubarb ,the using rhubarb combined with hydrochlorothiazide could increase the effective rate.Conclusions\ These results indicate that rhubarb play an important protective effect on live cirrhosis, and such protective effect may be related to reducing of TNF-α,endotoxin and NO release.
出处
《医师进修杂志》
北大核心
2003年第10期12-13,共2页
Journal of Postgraduates of Medicine
