摘要
目的：研究肿瘤坏死因子－α（ＴＮＦ－α）在肠源性内毒素血症中的作用及丹参防治肝损伤机制。方法：用硫代乙酰胺（ＴＡＡ）诱发大鼠急性肝损伤，检测血浆内毒素、ＴＮＦ－α及丙氨酸氨基转移酶（ＡＬＴ）水平变化，并与丹参治疗组进行比较。结果：ＴＡＡ诱发急性肝损伤大鼠血浆内毒素及ＴＮＦ－α含量升高，二者呈正相关；血浆ＡＬＴ亦升高，与ＴＮＦ－α亦呈正相关。丹参治疗组大鼠血浆ＴＮＦ－α及ＡＬＴ水平均低于肝损伤对照组。结论：ＴＡＡ引起肠源性内毒素血症，内毒素促进ＴＮＦ－α释放，ＴＮＦ－α进一步介导肝损伤。
AIM:To study the effects of tumor necrosis factor-αon gut-derived endotoxemia in rats and the preventive and therapeutive effects of Radix Salviac Miltiorrhizac (RSM). METHODS: Endotoxin, TNF-α and ALT (alanine aminotransferase) levels were determined in plasma of acute hepatic injury rats induced by TAA (thioacetamide), the results were compared with that obtained from RSM group. RESULTS:Plasma endotoxin and TNF-α levels were increased in rats of TAA group and there were a positive correlation between endotoxin and TNF-α contents ( r =0.8326, P<0.05 ).Plasma ALT contents also increased in TAA group and correlated with TNF-α level( r=0.8237, P<0.05 ).RSM decreased plasma TNF-α and ALT contents at the same time. CONCLUSION:TNF-α might played an important role in endotoxin-mediated hepatic injury. RSM may displayed its preventive and therapeutic effects by way of TNF-α level down-regulation.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1999年第1期51-53,共3页
Chinese Journal of Pathophysiology
关键词
肿瘤坏死因子Α
内毒素血症
丹参
肝损伤
Tumor necrosis factor
Liver diseases
Endotoxins
Drugs, Chinese herbal
