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基因治疗脊髓损伤研究进展 被引量：1

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作者 郭家松 曾园山 李海标
机构地区 中山大学中山医学院组织胚胎学教研室神经科学研究室
出处 《解剖与临床》 2002年第4期179-181,共3页 Anatomy and Clinics
基金 国家重点基础研究课题 G19990 5 40 0 9
关键词 基因治疗 脊髓损伤 神经营养因子 病毒载体 逆转录病毒
分类号 R651.2 [医药卫生—外科学] R394 [医药卫生—医学遗传学]
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参考文献16

  • 1[1]Siegal GJ, Chauhan NB. Neurotrophic factor in Alzheimer' s and Parkinson' s disease brain. Brain Res Rev,2000,33:199～227.
  • 2[2]Widenfalk J, Lundstromer K, Jubran M, et al. Neurotrophic factor and receptors in the immature and adult spinal cord after mechanical injury or kainic acid. J Neurosci,2001,21(10): 3457～3475.
  • 3[3]Tuszynski MH, Gage FH. Maintaining the neuronal phenotype after injury in the adult CNS. Neurotrophic factors, axonal growth substrates, and gene therapy. Mol Neurobiol, 1995,10(2 - 3): 151 ～ 167.
  • 4[4]Kim DH, Gutin PH, Noble LJ, et al. Treatment with genetically engineered fibroblasts producing NGF or BDNF can accelerate recovery from traumatic spinal cord injury in the adult rat. Neuroreport, 1996,7(13) :2221～2225.
  • 5[5]Blesch A, Tuszynski MH. Robust growth of chronically injured spinal cord axons induced by grafts of genetically modified NGF - secreting cells. Exp Neurol, 1997, 148(2) :444～452.
  • 6[6]Weider H, Blesch A, Grill RJ, et al. Nerve growth factorhypersecretting Schwann cell grafts augment and guide spinal cord axonal growth and remyelinae central nerve system axons in a plentypically appropriate manner that correlates with expression of L1. J Comp Neurol, 1999,413(4) :495～506.
  • 7[7]Tusztbski MH, Peterson DA, Ray J, et al. Fibroblasts genetically modified to produce nerve growth factor induce robust neuritic ingrowth after grafting to the spinal cord.Exp Neurol, 1994,126 : 1～4.
  • 8[8]Menei P, Montero - Menei C, Whittemore SR, et al.Schwann cells genetically modified to secrete human BDNF promote enhanced axonal regrowth across transected adult rat spinal cord. Eur J Neurosci, 1998, 10:607 ～621.
  • 9[9]Liu Y, Kim D, Himes BT, et al. Transplants of fibroblasts genetically modified to express BDNF promote regeneration of adult rat rubrospinal axons and recovery of forelimb function. J Neurosci, 1999,19 (11): 4370～43987.
  • 10[10]Grill R, Murai K, Blesch A, et al. Cellular delivery of neurotrophin- 3 promotes corticospinal axonal growth and partial functional recovery after spinal cord injury. J Neurosci, 1997,17(14): 5560～5572.

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同被引文献8

  • 1Blits B, Oudega M, Boer GJ, et al. Adeno-associated viral vectormediated neurotrophin gene transfer in the injured adult rat spinal cord improves hind-limc function[J]. Neurosci ,2003,118( 1 ) :271-281.
  • 2Zhou L, Baumgartner BJ, Hill-Felberg SJ, et al. Neurotrophin-3 expressed in situ induces axonal plasticity in the adult injured spinal cord[J] .J Neurosci,2003,23(4) :1424-1431.
  • 3Barkats M, Bilang-Bleuel A, Buc-Caron MH, et al. Adenovirus in the brain: recent advances of gene therapy for neurodegenerative diseases[ J]. Prog Neurobiol, 1998,55 (4): 333-341.
  • 4Dijkhuizen PA, Hemens WT, Teunis MA, et al. Adenoviral vectordirected expression of neurotrophin-3 in rat dorsal root ganglion explants results in a robust neurite outgrowth response[J]. J Neurobiol, 1997,33(2) :172-184.
  • 5Schnell L, Schneider R, Kolbeck R, et al. Neurotropin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion [ J ]. Nature, 1994,367 (6549): 170-173.
  • 6Senut MC, Tuszynski MH, Raymon HK, et al. Regional differences in responsiveness of adult CNS axons to grafts of cells expressing human neurotrophin-3 [ J ]. Exp Neurol, 1995,135 ( 1 ) :36-55.
  • 7赖燕来,孙朝晖,谢佐平.人神经营养素-3基因的克隆、表达及其活性检测[J].神经解剖学杂志,2004,20(1):7-11. 被引量：1
  • 8郭家松,曾园山,李海标,李晓君.NT-3基因修饰施万细胞与神经干细胞联合移植治疗全横断脊髓损伤的实验研究[J].解剖学报,2003,34(5):466-466. 被引量：8

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解剖与临床
2002年 第4期

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