摘要
目的 :观察 p5 3蛋白在甲状腺乳头状癌中的表达及临床意义。方法 :采用免疫组化 S- P法 ,对 68例甲状腺乳头状癌和 1 0例正常甲状腺组织检测 ,用有关统计学方法结合临床及随访资料进行分析。结果 :68例甲状腺乳头状癌中 ,p5 3蛋白阳性率为 2 7.9%。正常甲状腺组织阴性。甲状腺乳头状癌病理分级、有无淋巴结转移与 p5 3蛋白阳性表达率有关。结论 :甲状腺乳头状癌预后可能与 p5 3蛋白过度表达有关。
Objective:To observe the expression of p 53 protein in papillary adenocarcinoma of thyroid gland and its clinical significance.Methods:Sixty eight samples of with papillary adenocarcinoma of thyroid gland and 10 samples of normal thyroid were examined with S P method.Their clinical and follow up data were also analysed.Results:The positive expression rate of p53 protein was 27.9% in patients with papillary adenocarcinoma of thyroid gland,while the normal thyroid showed negative expression.The pathological grading and presence or absence of lymphatic metastasis of thyroid papillary adenocarcinoma were related to the positive expression of p53 protein.Conclusion:The expression of p53 protein may relate the prognosis of thyroid papillary adenocarcinoma.
出处
《广东医学院学报》
2001年第5期335-336,共2页
Journal of Guangdong Medical College
关键词
甲状腺肿瘤
免疫组化
P53蛋白
预后
thyroid neoplasm
immunohistochemistry
p53 protein
prognosis
