摘要
应用免疫组织化学技术对14例正常宫颈、20例宫颈良性病变、41例宫颈癌组织标本进行P53蛋白过度表达的检测,以了解其与宫颈癌发生的关系。结果正常宫颈和宫颈良性病变中均无P53蛋白过度表达,宫颈癌中P53蛋白过度表达阳性率为26.8%,表明P53蛋白过度表达可能与宫颈癌的发生有关(P<0.05),其在宫颈癌中表达阳性率不高,表明宫颈癌的发生是多因素共同作用的结果。
Overexpression of the P53 protein was detected with immunohistochemical method in 14 cases of normal cervical tissue,20 cases of benign cervical lesion and 41 cases of cervical cancer to study the relationship between overexpression of the P53 protein and the occurrence of cervical cancer.The results were that no overexpression of the P53 protein was detected in the 34 cases of normal cervix tissue and benign cervical lesion,and the positive rate was 26.8%in the cases of cervical cancer.The results showed that overexpression of the P53 protein may be involved in the occurrence of cervical cancer(P<0.05).The low positive rate in the cases of cervical cancer indicates that the occurrence of cervical cancer is the result of multiple factors.
作者
张蔚
陈惠祯
胡伦颖
高秉兰
Zhang Wei;Chen Huizhen;Hu Lunying(Department of Gynacology and Obstetrias,First Afiliated Hospital,Hubei Medical University,Wuhan 430060,China)
关键词
子宫颈肿瘤
P53基因
基因过度表达
cervix neoplasms
oncogene proteins
gene expression regulation,neoplastic
