摘要
目的 :测定头孢唑肟钠冻干粉注射剂的含量。方法 :采用反相高效液相色谱法 ,色谱柱为C18 柱 ,流动相为磷酸氢二钠柠檬酸缓冲液 -乙腈 (85∶15) ,流速为1 0ml/min ,检测波长为254nm。结果 :头孢唑肟钠的线性范围为4 1462～37 3156μg/ml(r=0 9999) ,精密度为0 6 %。结论 :本方法快速、准确 ,适合头孢唑肟钠冻干粉针的含量测定。
OBJECTIVE:To determine the content of ceftizoxime for injection METHODS:A RP-HPLC method was established,the polarls C18 was used as analysis column The mobile phase consisted of 0 23% sodium hydrogen phosphate and 0 14% trisodium buffer-acetonitrile(85∶15),the flow rate was 1 0ml/min,the detection wavelength was 254nm RESULTS:The linear range of ceftizoxime was 4 1 462～37 3 156μg/ml,r=0 9 999 The relative standard deviation was 0 6% CONCL_USION:The method is rapid,accurate and suitable for determination of content of ceftizoxime for injection
出处
《中国药房》
CAS
CSCD
2003年第11期687-688,共2页
China Pharmacy
