摘要
目的 观察肝硬化患者血清激活素A浓度变化及影响因素。方法 肝硬化 83例 (Child PughA级 3 2例 ,B级 3 0例和C级 2 1例 ) ,正常对照组 3 2例。血清激活素A、Ⅲ型前胶原肽、IV型胶原均采用酶联免疫吸附试验测定。结果 肝硬化患者血清激活素A升高 (1 3 3± 0 83ng/ml ,P <0 0 1) ;Child PughC级 (1 45± 0 3 9ng/ml)和B级 (1 47± 0 81ng/ml)分别较A级 (1 0 0± 0 3 5ng/ml,P <0 0 1)和正常对照组 (0 76± 0 .3 1ng/ml,P <0 0 1)升高 ,而A级与正常对照组、C级与B级之间血清激活素A水平无明显变化 (P>0 0 5) ,血清激活素A大于 1 13ng/m1的肝硬化患者中Chid PughB级和C级占 76 2 % (3 2 / 41)。在相应的Child Pugh分级中 ,并发肝性脑病、上消化道出血、继发感染及腹水患者中血清激活素A无明显变化 (P >0 0 5)。血清激活素A与Ⅲ型前胶原肽、IV型胶原和丙氨酸转氨酶 (ALT)呈正相关 (r=0 3 7,P <0 0 5;r=0 3 1,P <0 0 5;r=0 .2 4,P <0 .0 5) ,而与天门冬氨酸转氨酶 (AST)、胆汁酸、胆红素、清蛋白、凝血酶原时间无相关性 (P >0 0 5)。结论 肝硬化患者血清激活素A水平升高 。
Objective To evaluate the variarion of serum acitvin A level in liver c irrhotic patients Methods 83 liver cirrhotic patients (32 Child-Pugh A,30 Child-Pugh B and 21 Child-Pug h C) and 32 normal subjects entered the study The serum l evels of activin A,procollagen Ⅲ peptide and collagen Ⅳ were measured by ELISA ResultsCompared with those of normal subjects (0 76±0 31 ng/ml),the serum ac tivin A levels were significantly increased in liver cirrhotic patients (1 33± 0 83 ng/ml, P <0 01) The levels were higher in Child-Pugh C (1 45±0 39 ng/ml, P <0 01) and B (1 47±0 81 ng/ml, P <0 01) than thase in Child-Pugh A (1 00±0 3 5 ng/ml) and control group (0 76±0 31 ng/ml).There were no significa nt d ifference between Child-Pugh B and C patients ( P >0 05),or between Child- Pug h A patients and normal control ( P >0 05) 76 2% (32/41) patients whose s erum levels of activin A were higher than 1 13ng/ml belonged to Child-Pugh B and C gr oups In corresponding of Child-Pugh grades,the serum activin A levels of those suff ering from hepatic encephalopathy,digestive tract hemorrhage,infection or ascite s were not different from those of no sufferers ( P >0 05) Serum activin A was positively correlated with procollagen Ⅲ peptides,collagen IV and alanine am inotransferase ( r=0 37,P<0 05;r=0 31,P<0 05;r=0 24,P <0 05) Conclusions Serum activin A is increased in cirrhotic patients and activin A may invol ve in the pathogesis of hepatic cirrhosis
出处
《胃肠病学和肝病学杂志》
CAS
2003年第5期461-463,共3页
Chinese Journal of Gastroenterology and Hepatology
