摘要
目的:进一步探讨激活素A(activinA,ACTA)与肝纤维化的关系。方法:采用ELISA法测定112例各种病毒性肝炎患者及20例健康对照者血清ACTA、透明质酸(HA)及Ⅲ型前胶原(PCⅢ)水平,通过比较各组病毒性肝炎之间及健康对照组血清ACTA、HA、PCⅢ水平差异进行统计分析。结果:血清ACTA、HA、PCⅢ水平,从慢性肝炎轻、中度患者开始明显升高,以慢性重度、肝硬化组为最高,与其他两组比较有统计学意义(P<0.01),其升高程度与肝纤维化及肝病严重程度呈正相关。结论:动态检测血清ACTA、HA、PCⅢ水平可以做为反映慢性肝病肝纤维化程度和预后的指标。
Objective To research the correlation between activin A and liver fibrillation deeply. Method Using ELISA to determine the levels of ACTA hyaluronic acid （HA） and type Ⅲ precoUagen （pcⅢ） in the serum which is from 112 patients who have virus hepatitis and 20 healthy persons（as the control group）, and then make an statistic analysis by comparing the difference of AC- TA,HA, PCⅢ＇S levels in serum between hepatitis patients and control group. Results Levels of ACTA ,HA,PCⅢ in serum begin to rise from mild case ,medium chronic hepatitis patients,and the chronic severe case; hepatocirrhosis group is the highest,the differ- ence has its significance by comparing with the other two groups（P〈0.01）. Conclusion Determining the levels of ACTA,HA,PCⅢ in serum dtnamically can reflect the degree of chronic hver disease＇s liver fibrosis and its recovery.
出处
《吉林医学》
CAS
2006年第5期463-464,共2页
Jilin Medical Journal
