摘要
目的 :检测各型肝病患者血清α1 酸性糖蛋白 (α1 AGP)、谷丙转氨酶 (ALT)和谷草转氨酶 (AST)、白蛋白(ALB)含量的变化 ,观察在肝病中的临床意义 ,同时与非肝病患者和正常健康者作对照。方法 ::用罗氏生化 (α1 AGP)诊断试剂盒测定血清α1 AGP的含量。结果 :发现急性肝炎时 ,血清α1 AGP含量降低 ,ALT、AST升高 ,ALB无明显变化 ,尤其肝硬化 (失代偿 )、重症肝炎和重度慢性肝炎时 ,血清α1 AGP含量降低极为显著 (P <0 0 0 1) ,随病情好转 ,血清α1 AGP含量有所上升 ;肝癌时 ,血清α1 AGP含量却明显升高 (P <0 0 0 1) ,对肝细胞癌、肝硬化和肝炎的鉴别诊断有一定价值。结论 :①α1 酸性糖蛋白水平和肝脏病变的范围和损害程度明显相关 ,动态观察可作为病情预后观察的一项生化指标 ;②α1 酸性糖蛋白的检测对肝炎。
Objectives:To study the change of α1-acid glycoprotein and ALT,AST and ALB in persons with hepatitis,compared with the non-hepatitis persons and healthy persons as the control groups. Methods:Serum α1-acid glycoprotein was examined with α1-acid glycoprotein kit. Results:The concentration of α1-acid glycoprotein in sera of acute hepatitis decreased obviously. The ALT and AST levels increased. The level of ALB has not distinctive change. The more significant decrease of serum α1-acid glycoprotein level appeared in the patients with hepatocirrhosis(decompensatory) and severe hepatitis. With the diseases getting better,the serum concentration of α1-acid glycoprotein gradually increased. The concentration of α1-acid glycoprotein in live cancer was significantly higher than that of controls. The assay of α1-acid glycoprotein may be useful in differential diagnosis for hepatitis, hepatocirrhosis and liver cancer. Conclusions:① Serum α1-acid glycoprotein level was significantly correlated with types and process of hepatic diseases. ② Serially observing chang of serum α1-acid glycoprotein in process of hepatic diseases might be a biological prognostic marker.
出处
《四川省卫生管理干部学院学报》
2003年第3期169-171,共3页
Journal of Sichuan Continuing Education College of Medical Sciences
关键词
肝炎
肝硬化
肝癌
Α1-酸性糖蛋白
Hepatitis
Hepatocirrhosis
Liver cancer
α1-acid glycoprotein
