摘要
目的 了解鼻咽癌放疗过程中肿瘤组织金属硫蛋白表达的动态变化及其临床意义。方法 在我院作单纯放射治疗的鼻咽癌患者中随机抽取 46例 ,采用免疫组化方法检测肿瘤组织放疗前、中、后金属硫蛋白表达的动态变化 ,并分析其与鼻咽癌临床分期及放疗近期疗效的关系。结果 2 7例患者完成了放疗前、中、后 3次检测 ,放疗前金属硫蛋白表达率均值为 ( 3 9 85± 3 7 85 ) %,较正常对照显著升高 (P <0 0 5 ) ;放疗中、放疗后鼻咽癌组织中金属硫蛋白表达均显著下降 (P <0 0 5 ) ;放疗前、中、后肿瘤组织金属硫蛋白表达的动态变化与鼻咽癌临床分期和近期疗效无明显关系(P >0 0 5 )。结论 放疗前鼻咽癌组织金属硫蛋白表达异常升高 ,放疗中、放疗后显著下降 。
Objective To observe the dynamic change and clinical significance of the expression of metallothinein in tissue of nasopharyngeal carcinoma before, during, and after radiotherapy. Methods Forty-six patients received conventional radiotherapy alone for nasopharyngeal carcinoma were randomty selected for study. 26 persons without cancer were selected as normal control. Tissue samples were taken before, during, and after radiotherapy. The expression of metallothinein was detected by immunohistochemistry. Results Among Forty-six patients, 27 patients completed 3 tests for the expression of metallothinein. Among them, before radiotherapy, the expression rate of metallothinein in nasopharyngeal carcinoma tissues was (39 85±37 85)%, significantly higher than that in the control(12 12±22 41)%, ( P <0 05). During or after radiotherapy, the expressions rate of metallothinein in all patients decreased( P <0 05). And there were no correlations between the dynamic expression of metallothinein and the stage of nasopharyngeal carcinoma or the effect of radiotherapy for nasopharyngeal carcinoma( P >0 05). Conclusion The expression rate of metallothinein in nasopharyngeal carcinoma tissues is significantly higher before radiotherapy, and decrease during or after radiotherapy, suggesting that the ionizing radiation did not induce the metallothinein synthesis.
出处
《广东医学》
CAS
CSCD
2003年第11期1189-1191,共3页
Guangdong Medical Journal
基金
广东省广州市科学技术委员会基金资助项目(编号 :2 0 0 0 -J- 0 1 2 - 0 2 )
