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亚低温对大鼠急性脑损伤后血小板聚集功能的影响 被引量：4

The effects of hypothermia on platelet aggregation function after acute cerebral injury in rats
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摘要 目的　探讨亚低温治疗对血小板聚集功能的影响及其机制。方法　检测大鼠脑损伤亚低温治疗后血浆血小板计数 (BPC)、血小板聚集功能 (PagT)及血栓素B2 (TXB2 )和 6 酮前列腺素F1α(6 Keto PGF1α)的含量 ,并观察其变化趋势。结果　大鼠脑损伤后 6h内血小板趋向为高聚集状态 ,6h后反之 ;而亚低温治疗组 6h内血小板聚集功能较低 ,6h后则增强。结论　亚低温对脑损伤早期血小板高聚集状态的改善 ,可能与抑制TXA2 和增加PGI2 Objective To investigate the effects of hypothermia on platelet aggregation function and its mechanism. Methods We observed the content of BPC, PagT, TXB 2and 6-Keto- PGF 1α in plasm of brain-injured rats after treatment with hypothermia for 6 hours. Results Blood platelet aggregation function inclined to increase within 6 hours of the injury, but it decreased after 6 hours. Conversely, the blood platelet aggregation function remained in low level until 6 hours later. Conclusion The improvement of hypothermia on high blood platelet aggregation function in the early stage of brain injury may be related to the inhibition on TAX 2and increased concentration of PGI 2caused by hypothermia.
作者 巩守平 师蔚 王睿智 吕健 吴锋 车金
机构地区 西安交通大学第二医院神经外科 西安交通大学医学院血液病实验室
出处 《西安交通大学学报（医学版）》 CAS CSCD 北大核心 2003年第5期507-509,共3页 Journal of Xi’an Jiaotong University（Medical Sciences）
关键词 急性脑损伤 血小板聚集功能 亚低温治疗 血小板计数 血栓素B2 6-酮前列腺素F1Α hypothermia brain injury PagT TXB 2 6-Keto- PGF 1α
分类号 R651.15 [医药卫生—外科学] R454.5 [医药卫生—治疗学]
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参考文献12

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二级参考文献11

共引文献16

同被引文献38

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引证文献4

二级引证文献26

西安交通大学学报（医学版）
2003年 第5期

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