摘要
目的探讨玄芷镇痛片对急性血瘀模型大鼠血浆6-酮-前列腺素Flα(6-K-PGFlα)和血栓素B2(TXB2)的影响。方法 SD大鼠60只,随机分为正常对照组、模型组、阳性对照组、玄芷镇痛片1.36,2.72,5.44 g·kg-1组,共6组,各10只。采用皮下注射肾上腺素加冰水冷浴法制造大鼠血瘀模型,观察玄芷镇痛片对急性血瘀模型大鼠血浆6-KPGFlα、TXB2含量的影响。结果模型组与正常对照组比较,6-K-PGFlα水平降低(P<0.01),TXB2水平升高(P<0.01);玄芷镇痛片3个剂量组血浆中6-K-PGFlα水平均明显升高(均P<0.05),TXB2水平均明显降低(均P<0.05)。结论玄芷镇痛片对急性血瘀模型大鼠血浆6-K-PGFlα、TXB2均有明显调节作用,通过升高血浆6-K-PGFlα水平,降低TXB2水平,以纠正前列环素与血栓素A2之间的平衡失调。
Objective To investigate the effects of xuanzhi analgesic tablets on plasma levels of 6-keto-prostaglandin Flα（6-K-PGFlα） and thromboxane B2（TXB2） in rats with acute blood stasis. Methods Sixty SD rats were divided into six groups randomly, namely normal control, model control, positive control, xuanzhi analgesic tablets at 1. 36, 2. 72, and 5. 44 g＆#183;kg-1 groups. The rat model of blood stasis syndrome was caused by subcutaneous injection of adrenaline incorporated with ice-bathing. The effects of xuanzhi analgesic tablet on 6-K-PGFlαand TXB2 were observed. Results Compared with the normal control,plasma level of 6-K-PGFlα was significantly reduced（P〈0. 01） and that of TXB2 in the model control was evidently increased（P〈0. 01）. Three dosages of xuanzhi analgesic tablets significantly raised 6-K-PGFlαlevel（P〈0. 05）and lowered TXB2 level （P〈0. 05）. Conclusion Xuanzhi analgesic tablets significantly adjust plasma levels of 6-K-PGFlαand TXB2in rats with acute blood stasis. Xuanzhi analgesic tablets can coreect the imbalance between PGI2 and TXA2 through increasing 6-K-PGFlαand desearing TXB2 levels.
出处
《医药导报》
CAS
北大核心
2014年第5期573-574,共2页
Herald of Medicine
