摘要
目的 :研究重型脑损伤后血NO浓度变化与脑血管痉挛 (CVS)的关系。方法 :重型脑损伤病人 34例 ,入院时格拉斯哥评分GCS≤ 8分 ,入院后第 1～ 3天 ,4～ 7天 ,14天经颅多普勒超声 (TCD)测定大脑中动脉 (MCA)的血流速度及抽血分离血浆后测定NO的含量。结果 :19例 (5 6 % )发生脑血管痉挛 ;其中轻度 8例 ,中度 6例 ,重度 5例。痉挛组 (CVS)与非痉挛组 (non CVS)血NO浓度虽然在伤后均高于正常组 ,但两者存在明显差异 ,CVS组NO浓度升高程度与CVS的严重程度相符。结论 :重型脑损伤患者动态检测血NO含量变化 ,有助于判断伤后脑血管痉挛程度 ,对治疗具有指导意义。
s Objective:To elucidate the nitric oxide concentration changes and their relationship with posttraumatic cerebral vasospasm(CVS).Methods:Thirty four patients suffering from severe head injuries(GCS less than 8) were included into our study.Blood flow velocities were determined serially by TCD in MCA in day 1～3,4～7,14.meanwhile,concentration of plasma NO were measured serially in day 1～3,4～7,14,after severe head injury,and compared with those of normal volunteers.Results:CVS was found in 19 patients,the levels of NO in patients with and without CVS were significantly different.Conclusion:Detecting blood concentration of NO in patients with severe head injury is helpful to evaluate the extent of CVS,which is of instructive meaning to the following treatment.
出处
《广西医学》
CAS
2003年第11期2114-2116,共3页
Guangxi Medical Journal
