摘要
目的 :探讨老年 2型糖尿病 (T2DM)患者血清瘦素水平与胰岛素、胰岛素抵抗的关系。方法 :测定 85例T2DM患者空腹及餐后 2小时瘦素、血糖、胰岛素 (FLep、PLep、FBG、PBG、FIns、PIns)、糖化血红蛋白 (HbAic)、总胆固醇 (Ch)、甘油三酯 (Tg)、高密度脂蛋白胆固醇 (HDL ch) ,应用稳态模式胰岛素抵抗指数 (HOMA IR)作为胰岛素抵抗指标 ,进行比较、相关分析。结果 :肥胖组血清瘦素水平明显高于非肥胖组 (P <0 0 1) ,瘦素与BMI(r=0 5 715 ,P <0 0 1)、胰岛素 (r =0 5 175 ,P <0 0 1)、HOMA IR(r=0 6 873,P <0 0 1)明显正相关 ,与病程、年龄、血糖、HbAic、血脂 (P >0 0 5 )无关。结论 :瘦素是胰岛素抵抗的主要相关因素 ,在 2型糖尿病的发生。
Objective:To investigate the relationship between serum leptin and insulin,insulin resistance in aged patients with type 2 diabetes.Method:The fasting and posting serum leptin,glucose,insulin(FLep,PLep,FBG,PBG,FIns,PIns),HbAic,CH,TG,HDL ch in 85 patients were measured.Insulin resistance was estimated by HOMA IR and its relationship with leptin and insulin was analyzed.Results:The level of leptin in obesity patients was significantly higher than that in patients with normal weight(P<0 01),there was positive correlation between leptin and BMI(r=0 5715,P<0 01),insulin(r=0 5715,P<0 01),HOMA IR(r=0 6873,P<0 01),and there was no correlation between leptin and the stage of diabetes,age,glucose,HbAic,blood lipid(P>0 05).Conclusions:Leptin is the main correlation factor of insulin resistance,it play an important role in the development and progress of type 2 diabetes.
出处
《广西医学》
CAS
2003年第11期2110-2112,共3页
Guangxi Medical Journal
