急性脑出血患者血浆及脑脊液组织型纤溶酶原激活物及其抑制物含量的观察
摘要
目的 研究急性脑出血患者血浆及脑脊液组织型纤溶酶原激活物 (t PA)及其抑制物 (PAI 1)含量的变化及其临床意义。方法 采用双抗体夹心固相酶联免疫吸附法 (ELISA)检测 34例急性脑出血患者血浆和其中 2 1例患者脑脊液t PA及PAI 1抗原含量 ,并与正常对照组的血浆和脑脊液t PA、PAI 1含量进行比较。结果 急性脑出血组患者血浆及脑脊液t PA、PAI 1含量均显著高于对照组 (P <0 0 1,P <0 0 5 ) ;脑脊液中t PA、PAI 1的含量分别与血浆中t PA、PAI 1的含量呈正相关 (均P <0 0 5 )。结论 急性脑出血患者纤溶活性明显升高 ;t PA及PAI
出处
《临床神经病学杂志》
CAS
2003年第5期289-290,共2页
Journal of Clinical Neurology
参考文献10
-
1Loscalzo J, Bmwnwald E. Tissue plasminogen actiator. N Engl J Med,1988,319:925.
-
2Hoylaerts M, Rijken DC, Lijnen HR, et al. Kinetics of the activation of plasminogen by human tissue plasminogen activator; role of fibrin. J Biol Chem, 1982,257:2912.
-
3Agnelli G. Diurnal variation of tissue type plasminogen aetivator and its rapid inhibitor( PAI- 1 ). Circulation, 1985,72 : 178.
-
4Wiman B, Hamsten A. Impaired fibrinolysis and risk of thromboembolism. Progress in Cardiovascular Diseases, 1991,34:179.
-
5Kluft C. Constitutive synthesis of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1): coditions and therapeutic targets. Fibrinolysis, 1994,8:1.
-
6Lindgren A, Lindoff C, Norrving B, et al. Tissue plasminogen activator and plasminogen activator inldbitor-1 in stroke patients. Stroke, 1996,27:1066.
-
7Johansson L, Jansson JH, Bomant K, et al. Tissue plamninogen activator or plasminogen activator inhibitor-1 and t-PA/PAI-1 complex as risk factors for the development of a first stroke. Stroke,2000,31:26.
-
8de Baer JP, Abbink JJ, Brouwer MC, et al. PAI-1 synthesis in the human hepatoma cell line Hep G2 is increased by cytokines-evidence that the liver contributes to acute phase behaviour of PAI- 1. Thromb Haemost, 1991,65:181.
-
9Fujii Y, Tanaka R. Sedal changes in hemostasis after intracranial surgery. Neurosurgery, 1994,35 : 26.
-
10Freyburger G, Janvier G, Dief S, et al. Fibrinolytic and hemorheologic alteration during and after elective aortic graft surgery: implications for postoperative management. Anesth Analg, 1993,76:504.
-
1赵文洲,余绍祖,黄本友.急性脑血栓形成患者脑脊液组织型纤溶酶原激活物及其抑制物含量测定的意义[J].河南实用神经疾病杂志,2003,6(3):19-20.
-
2张贵斌,赵文洲,李峰.急性脑梗死患者血浆及脑脊液t-PA及PAI-1含量测定及其临床意义[J].山东医药,2002,42(14):4-5.
-
3赵文洲,余绍祖,黄本友.脑血栓形成病人血浆及脑脊液t-PA及其PAI-1含量的观察[J].中西医结合心脑血管病杂志,2003,1(2):71-73. 被引量：2
-
4赵文洲,罗韵文,余绍祖,黄本友.急性脑血栓形成患者血浆及脑脊液纤溶指标的观察[J].中国康复,2003,18(3):147-148.
-
5杨霄鹏,李秋芳,王金兰,娄委宇.急性脑梗死患者血浆t-PA和PAI的变化及临床意义[J].中国实用神经疾病杂志,2006,9(6):33-34. 被引量：10
-
6文芳,王永华,余绍祖.不同部位脑梗死病人脑脊液vWF含量的研究[J].卒中与神经疾病,1999,6(4):211-212. 被引量：4
-
7崔元孝,表倩,杨东鸾.高血压性脑出血急性期血中抗凝血酶Ⅲ水平的测定[J].山东医药,1999,39(2):4-5. 被引量：2
-
8宋爱群,张阳普,陈邦国,丁德光.电针对局灶性脑缺血再灌注模型大鼠血浆t-PA、PAI-1的影响[J].湖南中医杂志,2006,22(1):62-63. 被引量：2
-
9刘孟渊,王达平,郭阳波,刘广南,刘惠纯,郑朝盾,陆泳.阿尔茨海默病患者脑脊液中Fas抗原含量的变化[J].广东医学,2000,21(1):22-23. 被引量：1
-
10靳桂琴,王爱平.组织因子途径抑制物对缺血性脑血管病的诊断价值[J].河北医药,2000,22(5):356-357.
