摘要
采用双抗体夹心固相酶联免疫吸附法 (EL ISA)检测 3 5例急性脑梗死患者血浆和其中 3 1例患者脑脊液 t-PA及 PAI-1抗原含量 ,与 3 5例对照组血浆和其中 2 0例对照组脑脊液进行比较。结果 :急性脑梗死组血浆 t-PA含量高于对照组 ,PAI-1含量显著高于对照组 ;其脑脊液 t-PA、PAI-1含量均显著高于对照组 ;脑脊液中 t-PA、PAI-1的含量分别与血浆中 t-PA、PAI-1的含量呈正相关。认为急性脑梗死患者纤溶活性明显下降 ,t-PA及PAI-1参与了脑梗死之病理过程 ;t-PA及 PAI-1抗原含量是反映体内纤溶活性的两个重要指标 ;可用血浆或脑脊液 t-PA、PAI-1的含量作为判断病情的参考指标之一。
Plasma concentrations of tissue plasminogen activator (t PA) and plasminogen activator inhibitor 1 (PAI 1) antigen were determined in 35 patients with acute cerebral infarction and in 35 normal control subjects, cerebrospinal fluid concentrations of t PA and PAI 1 antigen were also determined in 31 patients with acute cerebral infarction and in 20 normal control subjects. The results showed that, in acute cerebral infarction group, the plasma concentrations of t PA antigen in patients were higher than those of normal control subjects (P<0.05); the plasma concentrations of PAI 1 antigen were significantly higher (P<0.01). The cerebrospinal fluid concentrations of t PA and PAI 1 antigen in the patients with acute cerebral infartion were significantly higher than those of normal control subjects; They were positively correlated with plasma concentrations of t PA and PAI 1 antigen.The neurological defect scores in patients with acute cerebral thrombosis were significantly positively correlated with plasma concentrations of t PA and PAI antigen.The fibrinolytic activity in the patients with acute cerebral thrombosis was significantly lower than normal. It suggests that the plasma t PA and PAI 1 might play a role in the pathologic changes of cerebral infarction. t PA and PAI 1 may be two important indexes of reflecting fibrinolytic activity.
出处
《山东医药》
CAS
北大核心
2002年第14期4-5,共2页
Shandong Medical Journal
关键词
急性脑梗死
血浆
脑脊液
T-PA
PAI-1
含量测定
临床意义
Infartion Tissue plasminogen activator Plasminogen activator inhibitor Plasma Cerebrospinal fluid
