摘要
目的 探讨转化生长因子 β1(TGF β1)对脑缺血再灌注损伤后肿瘤坏死因子 α(TNF α)表达的影响。方法 用线栓法建立大鼠局灶脑缺血再灌注模型 ,给模型大鼠侧脑室内注入不同剂量TGF β1或生理盐水 ,观察各组大鼠的神经功能缺损评分和脑组织中TNF α的表达。结果 大、小剂量TGF β1治疗组大鼠脑组织TNF α表达较对照组均明显降低 ,神经功能缺损评分亦明显下降 ,大、小剂量治疗组之间比较无明显差异。结论 TGF β1对脑缺血再灌注损伤具有保护作用 ,其机制可能为抑制TNF α表达 ,并且其保护作用与剂量无明显关系。
Objective To investigate the influence of transforming growth factor β 1 to expression of tumor necross factor α(TNF α) after cerebral ischemic reperfusion injury.Methods Using thread embolism method to develop the model of focal cerebral ischemic reperfusive injury in rats, different dose of TGF β 1 or 0 9% NaCl was injected intracerebroventricularly.Neurological functional dificit scales in the different dose of TGF β 1 groups and the expression of TNF α were observed Results In both big and small dose of TGF β 1 groups,the expression of TNF α decreased after cerebral ischemic reperfusion,and the neurological functional dificit scales were significantly lower than those of the control.There was no significant difference between the group of big and small dose of TGF β 1 Conclusion TGF β 1 may have a protective effect on cerebral ischemic reperfusive injury by inhibiting expression of TNF α,and it may be irrelative with the dose
出处
《临床神经病学杂志》
CAS
2003年第5期278-280,共3页
Journal of Clinical Neurology
